Development And Validation Of Stability Indicating RP-HPLC Method For Simultaneous Estimation Of Remogliflozin And Vildagliptin In Pharmaceutical Dosage Form.

Registration ID: IJNRD_181134

Published ID: IJNRD2204118

DOI: Click Here to Get

Patel Richiben Vinodbhai , Dr. Hiral Panchal , Ms. Foram Patel , Ms. Ayushi Patel

Remogliflozin etabonate, RP-HPLC, Method Development, Stability Study, Validation

The present study was focused to develop a simple, precise, accurate and cost effective RP-HPLC method for estimation of Remogliflozin etabonate and Vildagliptin from pharmaceutical dosage form. The chromatographic method was carried out using Agilent C18 (150mm*4.6mm) 5µm using mobile phase (Methanol: Buffer (pH3.5): ACN (55:35:10 %v/v)). The flow rate was set 1.0ml/min with 20µL injection volume. Total run time 10min. Detection was carried out at wavelength of 254nm. The detector response was linear in the range of 150-450μg/ml for Remogliflozin etabonate and 75-225μg/ml for Vildagliptin. The % recoveries for Remogliflozin etabonate and Vildagliptin obtained in the accuracy study were 99.07-100.38% and 99.69-100.70% respectively. The LOD for Remogliflozin etabonate and Vildagliptin were found to be 0.0053μg/ml and 0.0038μg/ml respectively. LOQ for Remogliflozin etabonate and Vildagliptin were found to be 0.016μg/ml and 0.0011μg/ml respectively. Remogliflozin etabonate and Vildagliptin were also subjected to various stress condition like acid and alkali hydrolysis, oxidation, photolysis, and thermal degradation. The developed method is successfully applied for estimation of Remogliflozin etabonate and Vildagliptin from pharmaceutical dosage form.

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Patel Richiben Vinodbhai, Dr. Hiral Panchal, Ms. Foram Patel, & Ms. Ayushi Patel (April-2022). Development And Validation Of Stability Indicating RP-HPLC Method For Simultaneous Estimation Of Remogliflozin And Vildagliptin In Pharmaceutical Dosage Form.. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 7(4), 930-964. https://ijnrd.org/papers/IJNRD2204118.pdf

Volume 7 Issue 4, April-2022

Pages : 930-964

Paper Reg. ID: IJNRD_181134

Published Paper Id: IJNRD2204118

Downloads: 000121980

Research Area: Pharmacy

Country: Ahmedabad, Gujarat, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2204118.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2204118

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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