Paper Title
FORMULATION AND EVALUATION OF GASTRORETENTIVE FLOATING TABLET OF LOVASTATIN BY USING NATURAL POLYMERS
Article Identifiers
Registration ID: IJNRD_327153
Published ID: IJNRDTH00257
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Keywords
Lovastatin, Gastroretentive tablet, Floating drug delivery, Sustained release, Hyperlipidaemia, BCS Class II, Guar gum, In vitro buoyancy, Bioavailability enhancement, Release kinetics.
Abstract
The present study focuses on the formulation and evaluation of gastroretentive floating tablets of Lovastatin with the objective of improving its solubility, enhancing gastric retention time, and achieving sustained drug release. Lovastatin, a lipid-lowering agent categorized under BCS Class II, suffers from poor aqueous solubility and limited oral bioavailability due to its narrow absorption window in the upper gastrointestinal tract. To overcome these limitations, nine formulations (F1–F9) were prepared using the direct compression method by varying the concentrations of natural and synthetic polymers such as guar gum, HPMC, and carbopol, along with sodium bicarbonate as a gas-generating agent. Preformulation studies including organoleptic characteristics, melting point analysis, solubility testing, UV spectroscopy, and FTIR confirmed the purity and compatibility of Lovastatin with selected excipients. The pre-compression parameters such as bulk density, tapped density, Carr’s index, Hausner’s ratio, and angle of repose revealed good to acceptable flow characteristics. Post-compression evaluations showed uniform weight, adequate hardness, low friability, and consistent drug content across all batches. In vitro buoyancy studies indicated rapid floating within 60 seconds and prolonged floatation for over 12 hours. Drug release studies in 0.1N HCl demonstrated sustained drug release, with formulation F6 showing the highest cumulative drug release (~96%) over 12 hours. Drug release kinetics revealed that most formulations followed Higuchi and Korsmeyer–Peppas models, suggesting that the drug release was governed by a combination of diffusion and erosion mechanisms. In conclusion, the developed gastroretentive floating tablets of Lovastatin offer a promising approach to improve its bioavailability and therapeutic efficiency. The optimized batch (F6) showed potential for further in vivo and clinical studies for effective management of hyperlipidaemia.
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How To Cite (APA)
Mr.Mahesh Raosaheb Jagtap, Mr.Pratik D. Patil, & Dr.Vinod A. Bairagi (August-2026). FORMULATION AND EVALUATION OF GASTRORETENTIVE FLOATING TABLET OF LOVASTATIN BY USING NATURAL POLYMERS. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 11(8), 780-848. https://ijnrd.org/papers/IJNRDTH00257.pdf
Issue
Volume 11 Issue 8, August-2026
Pages : 780-848
Other Publication Details
Paper Reg. ID: IJNRD_327153
Published Paper Id: IJNRDTH00257
Research Area: Pharmacy All
Author Type: Indian Author
Country: Nashik, Maharashtra, India
Published Paper PDF: https://ijnrd.org/papers/IJNRDTH00257.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRDTH00257
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