Paper Title
Development of Novel Stationary Phases for High-Performance Liquid Chromatography (HPLC) Separation of Complex Organic Mixtures
Article Identifiers
Authors
Elsa Ansari
Keywords
HPLC, stationary phases, C18-modified silica gel, chromatographic separation, organic mixtures, column efficiency, mobile phase optimization
Abstract
This study presents the development and characterization of novel stationary phases for High-Performance Liquid Chromatography (HPLC) aimed at improving the separation efficiency of complex organic mixtures. Three stationary phases were synthesized: C18-modified silica gel, aminopropyl-modified silica gel, and cyanopropyl-modified silica gel. These phases were packed into stainless steel HPLC columns and evaluated under various chromatographic conditions. The C18-modified phase demonstrated superior retention, resolution, and efficiency across a range of analytes. The study also explored the impact of different mobile phase compositions and elution modes. Reproducibility, stability, and long-term performance were assessed, confirming the robustness of the developed stationary phases. The results indicate that the novel stationary phases provide enhanced chromatographic performance, making them suitable for the separation of complex organic mixtures in various analytical applications.
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How To Cite (APA)
Elsa Ansari (August-2024). Development of Novel Stationary Phases for High-Performance Liquid Chromatography (HPLC) Separation of Complex Organic Mixtures. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(8), c226-c239. https://ijnrd.org/papers/IJNRD2408226.pdf
Issue
Volume 9 Issue 8, August-2024
Pages : c226-c239
Other Publication Details
Paper Reg. ID: IJNRD_226609
Published Paper Id: IJNRD2408226
Downloads: 000121986
Research Area: Engineering
Country: -, -, Pakistan
Published Paper PDF: https://ijnrd.org/papers/IJNRD2408226.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2408226
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Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)
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This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition
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