Development of Novel Stationary Phases for High-Performance Liquid Chromatography (HPLC) Separation of Complex Organic Mixtures

Development of Novel Stationary Phases for High-Performance Liquid Chromatography (HPLC) Separation of Complex Organic Mixtures

Registration ID: IJNRD_226609

Published ID: IJNRD2408226

DOI: Click Here to Get

Elsa Ansari

HPLC, stationary phases, C18-modified silica gel, chromatographic separation, organic mixtures, column efficiency, mobile phase optimization

This study presents the development and characterization of novel stationary phases for High-Performance Liquid Chromatography (HPLC) aimed at improving the separation efficiency of complex organic mixtures. Three stationary phases were synthesized: C18-modified silica gel, aminopropyl-modified silica gel, and cyanopropyl-modified silica gel. These phases were packed into stainless steel HPLC columns and evaluated under various chromatographic conditions. The C18-modified phase demonstrated superior retention, resolution, and efficiency across a range of analytes. The study also explored the impact of different mobile phase compositions and elution modes. Reproducibility, stability, and long-term performance were assessed, confirming the robustness of the developed stationary phases. The results indicate that the novel stationary phases provide enhanced chromatographic performance, making them suitable for the separation of complex organic mixtures in various analytical applications.

Published Paper   E-Certificate

"Development of Novel Stationary Phases for High-Performance Liquid Chromatography (HPLC) Separation of Complex Organic Mixtures", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.9, Issue 8, page no.c226-c239, August-2024, Available :https://ijnrd.org/papers/IJNRD2408226.pdf

Volume 9 Issue 8, August-2024

Pages : c226-c239

Paper Reg. ID: IJNRD_226609

Published Paper Id: IJNRD2408226

Downloads: 000121193

Research Area: Engineering

Country: -, -, Pakistan

Published Paper PDF: https://ijnrd.org/papers/IJNRD2408226.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2408226

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJNRD (IJ Publication) Janvi Wave

This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition

Call For Paper - Volume 10 | Issue 8 | August 2025

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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (IJNRD) aims to explore advances in research pertaining to applied, theoretical and experimental Technological studies. The goal is to promote scientific information interchange between researchers, developers, engineers, students, and practitioners working in and around the world. IJNRD will provide an opportunity for practitioners and educators of engineering field to exchange research evidence, models of best practice and innovative ideas.

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