Paper Title
Formulation and development of catechin based nanogel for gingivitis
Article Identifiers
Authors
Monika Ankush Khambalkar , Pooja Yashwant Patil , Megha Nivrutti Kapashikar , HD Jedage , Vittal Rambhau Sangale
Keywords
Gingivitis, Catechin, Nanogel.
Abstract
This thesis focuses on the formulation and development of a novel catechin-based nanogel for the targeted delivery of catechin hydrate to gingival tissues, aiming to address the limitations of conventional therapies in gingivitis management. Nanogel formulation was formulated using Carbopol 934 and Poloxamer 407 polymers, was meticulously designed to encapsulate catechin hydrate efficiently and ensure sustained release kinetics in the oral cavity. The Nanogel was evaluated for its Homogeneity, pH, Spreadability, Particle size & Zeta potential, Viscosity, In- vitro release study and stability profile of the catechin-based nanogel formulation through a series of in vitro experiments and analyses. The In-vitro release of Catechin hydrate Nanogel was observed in the range of 83.746%- 94.846%. Initial burst release studies revealed rapid onset of therapeutic action, followed by sustained release kinetics, maintaining therapeutic levels of catechin hydrate over an extended period. Moreover, the stability study conducted over a three- month period confirmed the robustness and integrity of the nanogel formulation. The developed formulation exhibited favorable properties, including uniform particle size distribution, mucoadhesive properties, and compatibility with oral tissues.
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How To Cite (APA)
Monika Ankush Khambalkar, Pooja Yashwant Patil, Megha Nivrutti Kapashikar, HD Jedage, & Vittal Rambhau Sangale (August-2024). Formulation and development of catechin based nanogel for gingivitis. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(8), b439-b458. https://ijnrd.org/papers/IJNRD2408136.pdf
Issue
Volume 9 Issue 8, August-2024
Pages : b439-b458
Other Publication Details
Paper Reg. ID: IJNRD_226436
Published Paper Id: IJNRD2408136
Downloads: 000121993
Research Area: Pharmacy
Country: Udgir, Maharashtra, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2408136.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2408136
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Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)
ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016
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This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition
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