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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | Linking of Type-2 Diabetes Mellitus with oxidative damage and Cancer |
| Authors Name: | Charu bala Asthana |
| Download E-Certificate: | Download |
| Author Reg. ID: |
IJNRD_205942
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| Published Paper Id: | IJNRD2309389 |
| Published In: | Volume 8 Issue 9, September-2023 |
| DOI: | |
| Abstract: | The prevalence of diabetes mellitus (DM) is growing exponentially worldwide at an epidemic proportion . This chronic disorder has a negative effect on most metabolic pathways and contributes to the pathophysiology of diabetes complications . Persistent hyperglycemia induces oxidative stress and is suggested to play a prominent role in T2DM. The objective of this review is to summarize the findings of published research that investigated the relationship between diabetes mellitus and cancer.Current study aimed to correlate the status of biochemical indices in reference to increased glucose in T2DM subjects . A total of 117 subjects consisting of control (57) and T2DM patients (60) were included.Two groups were created based on levels of HbA1c( I-5.35±0.32,II-7.50±1.58).FBG(p value<0.001),TG(p value<0.05),HDL-C(<0.05),MDA (p value<0.001) and CA19-9(p value 0.005) were measured. Level of significance predicts hyperglycemic status influenced oxidative damage and pancreatic cancer.This study is conducted in Meerut in the year 2021. |
| Keywords: | DM-Diabetes Mellitus, SOD-superoxide dismutase ,CAT-catalase , GLT-glutathione,RNS- reactive nitrogen species, Nf-κb- nuclear factor kappa b, p38 MAPK-p38 mitogenactivated protein kinases, JNK/SAPK-stress-activated protein kinase/c-Jun NH(2)-terminal kinase,PKC- Protein Kinase C, AGE/RAGE-advanced glycation end product/receptor for AGE,ROOH-Reactive Hydroperoxides, GLUT-4-Glucose Transporter, PPAR-γ-peroxisome proliferator-activated receptor gamma), CEB/Ps-CCAAT enhancer-binding proteins,nuclear factor-1, p85, HIF-1α-hypoxia-inducible factors alpha, MEF2-myocyte enhancer factor 2, 8-OHdG- Hydroxydeoxyguanosine ,T2DM-Type-2 Diabetes Mellitus,PKC-Protein Kinase C,HbA1c-Glycosylated Hemoglobin, FBG-Fasting Blood Glucose,TG-Triglycerides,HDL-C-High Density Lipoprotein,MDA-Malondialdehyde,CA19-9-Cancer Antigen. |
| Cite Article: | "Linking of Type-2 Diabetes Mellitus with oxidative damage and Cancer", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 9, page no.d740-d764, September-2023, Available :http://www.ijnrd.org/papers/IJNRD2309389.pdf |
| Downloads: | 000118761 |
| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2309389 Registration ID: 205942 Published In: Volume 8 Issue 9, September-2023 DOI (Digital Object Identifier): Page No: d740-d764 Country: Dehradun, Uttarakhand, India Research Area: Medical Science Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2309389 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2309389 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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