INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016
Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI)
Alzheimer's disease (AD) is an ageing disorder characterized by cognitive impairment and memory deficits or dementia. Despite extensive research, effective treatments for AD are still lacking. However, recent strides in synthetic chemistry have opened new avenues for the design and development of small molecules targeting the key pathological features of AD. This comprehensive scientific review highlights the latest advancements in the chemistry of synthetic molecules for AD therapy, with a primary focus on their potential impact in combating the disease. Additionally, researchers have been investigating hybrid molecules capable of targeting multiple biological pathways simultaneously. Moreover, various synthetic approaches were attempted to conjugate two distinct synthons effectively. In the field of medicinal chemistry, heterocyclic scaffolds have been applied to create novel AChE and BuChE inhibitors for AD treatment. A thorough SAR has been established to guide the discovery of new AD medications. Meanwhile, the recent medicinal chemistry strategies were used to designed novel molecules such as, structure-based drug design, molecular hybridization etc. These methodologies were utilized in the scaffold of rivastigmine and donepezil drug and researchers identified novel small molecules with potential activity for AD therapy. In recent research, scientists developed a novel compound with bifunctional groups targeting the τ-protein, which can lead to nerve cell damage and death.
"Recent Updates in Chemistry of Alzheimer's Synthetic Molecules: A novel insight into the drug discovery", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 9, page no.d432-d450, September-2023, Available :http://www.ijnrd.org/papers/IJNRD2309355.pdf
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2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
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