Paper Title
Preparation And Evaluation of Fast Dissolving Tablets of Atenolol With Combination of Different Concentrations of Superdisintegrants By Direct Compression Technique
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Keywords
Atenolol, fast dissolving Tablets (FDTs), Superdisintegrants
Abstract
The purpose of this research was to formulate fast dissolving tablets (FDT) In the present work efforts have been made to prepare and evaluate fast dissolving tablets of atenolol with combination of different concentrations of superdisintegrants crospovidone, sodium starch glycolate by direct compression technique. fast dissolving tablets are designed to disintegrate and dissolve in saliva and then easily swallowed without need of water which is a major benefit over conventional dosage form. Atenolol, a β1-blocker, is prescribed widely in diverse cardiovascular diseases, eg, hypertension, angina pectoris, arrhythmias, and myocardial infarction. preparation and evaluation preparation of atenolol fast dissolving tablet with combination of different concentrations of superdisintegrants crospovidone, sodium starch glycolate by direct compression technique. The results revealed that the increased proportion of various superdisintegrants were associated with increase in the overall cumulative drug release rate. The developed tablets were evaluated for hardness, friability, drug content, weight variation, uniformity of dispersion, wetting time, wetting volume, in vitro dispersion time, in vitro disintegration time and in vitro drug release. The dissolution profiles of prepared tablets were compared with pure drug and marketed product. Rapid disintegration of tablets formulated in this research possibly help in administration
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How To Cite (APA)
Lakshmi Radhika G, Chandan NJ, Aroodha V Maragur, & Lalu Gowda V (September-2023). Preparation And Evaluation of Fast Dissolving Tablets of Atenolol With Combination of Different Concentrations of Superdisintegrants By Direct Compression Technique. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(9), a600-a610. https://ijnrd.org/papers/IJNRD2309073.pdf
Issue
Volume 8 Issue 9, September-2023
Pages : a600-a610
Other Publication Details
Paper Reg. ID: IJNRD_205038
Published Paper Id: IJNRD2309073
Downloads: 000122256
Research Area: Engineering
Author Type: Indian Author
Country: -, -, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2309073.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2309073
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