Review on Potential Activity of synthetic coumarins as Anti-Inflammatory agents

Review on Potential Activity of synthetic coumarins as Anti-Inflammatory agents

Registration ID: IJNRD_206500

Published ID: IJNRD2304734

DOI: Click Here to Get

Anita Singh , Sakshi Gupta , Komalpreet Kaur , Amrita Verma Pargaien

Coumarins, Inflammation, NSAIDs, Cyclooxygenase, TNF-Alpha

Inflammation is a defense mechanism used by body tissues to protect them against stimuli that they perceive to be harmful, such as pathogens, damaged cells, and irritants. The most common treatments for inflammation are nonsteroidal anti-inflammatory drugs (NSAIDs). Coumarin and its derivatives have some basic pharmacological properties like anti-inflammatory, anti-coagulant, antibacterial, antifungal, anti-HIV, antioxidant, antidepressants, antidiabetic, anti-allergic, anti-cancer, anti-proliferative, and antiviral. The purpose of this review is to investigate the synthetic scheme of novel coumarin derivatives that have been reported to have COX-1, COX-2, and TNF-alpha inhibitor activity. Various of the compounds described have also undergone in-vivo testing. Also, we performed in-silico study of various lead compounds originated from mentioned synthetic strategies against 4PH9 and 2AZ5 receptor.

Published Paper   E-Certificate

"Review on Potential Activity of synthetic coumarins as Anti-Inflammatory agents", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.8, Issue 4, page no.h263-h274, April-2023, Available :https://ijnrd.org/papers/IJNRD2304734.pdf

Volume 8 Issue 4, April-2023

Pages : h263-h274

Paper Reg. ID: IJNRD_206500

Published Paper Id: IJNRD2304734

Downloads: 000121127

Research Area: Pharmacy

Country: Bhimtal, Uttarakhand, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2304734.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2304734

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJNRD (IJ Publication) Janvi Wave

This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition

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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (IJNRD) aims to explore advances in research pertaining to applied, theoretical and experimental Technological studies. The goal is to promote scientific information interchange between researchers, developers, engineers, students, and practitioners working in and around the world. IJNRD will provide an opportunity for practitioners and educators of engineering field to exchange research evidence, models of best practice and innovative ideas.

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