Paper Title
Review on Potential Activity of synthetic coumarins as Anti-Inflammatory agents
Article Identifiers
Authors
Anita Singh , Sakshi Gupta , Komalpreet Kaur , Amrita Verma Pargaien
Keywords
Coumarins, Inflammation, NSAIDs, Cyclooxygenase, TNF-Alpha
Abstract
Inflammation is a defense mechanism used by body tissues to protect them against stimuli that they perceive to be harmful, such as pathogens, damaged cells, and irritants. The most common treatments for inflammation are nonsteroidal anti-inflammatory drugs (NSAIDs). Coumarin and its derivatives have some basic pharmacological properties like anti-inflammatory, anti-coagulant, antibacterial, antifungal, anti-HIV, antioxidant, antidepressants, antidiabetic, anti-allergic, anti-cancer, anti-proliferative, and antiviral. The purpose of this review is to investigate the synthetic scheme of novel coumarin derivatives that have been reported to have COX-1, COX-2, and TNF-alpha inhibitor activity. Various of the compounds described have also undergone in-vivo testing. Also, we performed in-silico study of various lead compounds originated from mentioned synthetic strategies against 4PH9 and 2AZ5 receptor.
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How To Cite (APA)
Anita Singh, Sakshi Gupta, Komalpreet Kaur, & Amrita Verma Pargaien (April-2023). Review on Potential Activity of synthetic coumarins as Anti-Inflammatory agents. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(4), h263-h274. https://ijnrd.org/papers/IJNRD2304734.pdf
Issue
Volume 8 Issue 4, April-2023
Pages : h263-h274
Other Publication Details
Paper Reg. ID: IJNRD_206500
Published Paper Id: IJNRD2304734
Downloads: 000121982
Research Area: Pharmacy
Country: Bhimtal, Uttarakhand, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2304734.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2304734
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Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)
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This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition
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