Inhaled Insulin – An Overview on Current Direction of Insulin Research

Registration ID: IJNRD_192489

Published ID: IJNRD2304531

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Dr. Bhumika Chandrakar

Afrezza, Diabetes, Glycemic control, Hemoglobin A1c, Inhalation, Insulin, Type 1 diabetes, Type 2 diabetes

Diabetes Mellitus (DM) is a metabolic disorder characterized by relative or absolute deficiency of insulin, resulting in hyperglycemia. Subcutaneous insulin and Oral Hypoglycaemic Agents (OHA) constitute the main treatment option for DM. Insulin is administered by injection or continuous infusion to control glucose levels mainly in Type I diabetes. Newer routes both oral and non oral, for insulin administration are current direction of insulin research as insulin injection therapy is burdensome and painful for many patients. Inhalational insulin is an attractive alternative for systemic administration of insulin given its accessibility and large alveolar-capillary network of lungs for drug absorption. Inhaled insulin has proven to be viable and, in some aspects, a more effective alternative to subcutaneous insulin. Past and present insulin inhaler devices have not found clinical or commercial success. Insulin inhalers create a dry powder or soft mist insulin aerosol, which does not provide the required uniform particle size or aerosol volume for deep lung deposition. Methods: The primary focus of this review is to investigate the potential treatment of diabetes with a wet insulin aerosol. Afrezza, inhaled insulin has been recently approved by Food and Drug Administration (FDA). It is a new, quicker acting inhalable insulin with a different and safer pharmacokinetic profile in comparison to previously failed inhaled form of insulin.

Published Paper   E-Certificate

Dr. Bhumika Chandrakar (April-2023). Inhaled Insulin – An Overview on Current Direction of Insulin Research. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(4), f293-f295. https://ijnrd.org/papers/IJNRD2304531.pdf

Volume 8 Issue 4, April-2023

Pages : f293-f295

Paper Reg. ID: IJNRD_192489

Published Paper Id: IJNRD2304531

Downloads: 000122006

Research Area: Pharmacy

Author Type: Indian Author

Country: Bhilai , Chhattisgarh , India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2304531.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2304531

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