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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | Development Of Validated Quantitative Analytical Methods For Pharmaceutical Formulation Of Eliglustat |
| Authors Name: | R.T. Lohiya , Komal P. Wahane , Milind J. Umekar |
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IJNRD_185007
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| Published Paper Id: | IJNRD2304198 |
| Published In: | Volume 8 Issue 4, April-2023 |
| DOI: | |
| Abstract: | A simple, accurate ,precise, rapid analytical method for the estimation of Eliglustat. The λ max of Eliglustat in methanol was found to be 282nm. All five methods of UV –spectrophotometry based upon zero order , first order and second order derivative have been established considering amplitude and area under curve of the spectrum. In RP-HPLC method, the condition were optimized to obtain an adequate separation of eluted compounds. Mobile phase and flow rate selection was based on peak parameters (height, tailing , theoretical plates, capacity or symmetry factor), run time and resolution. The mobile phase contain Methanol : Acetonitrile( 75:25) with flow of rate 1.2ml/min. the wavelength for detection was 282 nm at which better response for both the drugs was obtained. The retention time of eliglustat was found to be 4.09. The system suitability tests were carried out on freshly prepared stock solution . The calibration curve was linear in concentration range 80ug/ml to 130ug/ml regression 0.999.The method was checked by doing validation according to ICH guidelines. Hence the method is validated it is used for the routine analysis of eliglustat in its pharmaceutical dosage form by RP-HPLC |
| Keywords: | Eliglustat , Acetonitrile, Methanol, UV-Visible spectroscopy. |
| Cite Article: | "Development Of Validated Quantitative Analytical Methods For Pharmaceutical Formulation Of Eliglustat", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 4, page no.b752-b763, April-2023, Available :http://www.ijnrd.org/papers/IJNRD2304198.pdf |
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| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2304198 Registration ID: 185007 Published In: Volume 8 Issue 4, April-2023 DOI (Digital Object Identifier): Page No: b752-b763 Country: Nagpur, Maharashtra, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2304198 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2304198 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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