Paper Title
MONOCLONAL ANTIBODIES: A NOVEL APPROACH FOR THE TREATMENT OF EARLY ALZHEIMER'S
Article Identifiers
Registration ID: IJNRD_190919
Published ID: IJNRD2304195
: http://doi.one/10.1729/Journal.33770
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Keywords
Alzheimer’s disease, disease-modifying therapies, monoclonal antibodies, clinical trials, Lecanemab, Aducanumab
Abstract
Alzheimer’s is a progressive neurodegenerative disorder primarily characterized in the form of dementia. The underlying pathology of this condition is defined by deposition of beta amyloids and neurofibrillary tangles. No drug has shown prevention or cure of this condition. The Amyloid hypothesis suggests progression of Alzheimer’s could be halted by removing beta amyloids in brain. Thus, monoclonal antibodies (mAbs) have become an area of focus on research as disease modifying therapies in Alzheimer’s. Several clinical trials are going on but some of them have proven that mAbs in early Alzheimer’s could reduce the clinical decline of behavioral and cognitive function. US FDA has provided approval for Aducanumab and Lecanemab for the treatment of early Alzheimer’s through accelerated approval pathway. This review focuses the safety and efficacy profiles of mAbs including Aducanumab, Lecanemab, Ganeteneumab, Crenezumab, Donanezumab, Bapineuzumab and Solanezumab. Since there was lack of post-marketing surveillance, the clinical benefit of these medications is yet to be confirmed. In this review, we discuss the potential disease-modifying agents studied in clinical trials and update the information of mAbs that are still under clinical evaluation.
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How To Cite (APA)
JAYASHEELA .S. HIREMATH, AHM VISWANATHA SWAMY, ANCHU S P, JOBNA MERENA ABRAHAM, & SHRUTHI SREEKUMAR (April-2023). MONOCLONAL ANTIBODIES: A NOVEL APPROACH FOR THE TREATMENT OF EARLY ALZHEIMER'S. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(4), b706-b715. http://doi.one/10.1729/Journal.33770
Issue
Volume 8 Issue 4, April-2023
Pages : b706-b715
Other Publication Details
Paper Reg. ID: IJNRD_190919
Published Paper Id: IJNRD2304195
Research Area: Pharmacy
Author Type: Indian Author
Country: HUBBALLI, DHARWAD, KARNATAKA, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2304195.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2304195
Crossref DOI: http://doi.one/10.1729/Journal.33770
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