Formulation and Evaluation of Fast Dissolving Sublingual Film of Benidipine Hydrochloride for the Treatment of Hypertension

Registration ID: IJNRD_186808

Published ID: IJNRD2301351

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Mayank Sahu, Ankit Anchliya, Bhavana Sahu, Kapil Sahu, Damini Sahu

Hypertension, Sodium starch glycolate, ?-cyclodextrin, Sublingual film.

The sublingual route is very useful for quick onset of action and improved patient compliance. It improves drug utilization and the efficacy of active pharmaceutical ingredients. The oral route is the most preferred by patients. A fast dissolving oral drug delivery system is a solid dosage form that disintegrates or dissolves in the mouth in seconds without the use of water or chewing. The solubility and bioavailability of the drug were enhanced using solid dispersion. The solid dispersion of Benidipine hydrochloride: β-cyclodextrin was prepared in different ratios (1:1, 1:2, 1:3, 1:4) by physical mixture method. The current study discusses the formulation aspects, manufacturing methods such as solvent casting, evaluation parameters, and applications of fast dissolving films by the sublingual route made from polymers such as HPMC E-5, as a film forming agent Sodium starch glycolate, as a super disintegrating agent, Critic acid, as a saliva stimulating agent PEG 400 as a plasticizer and Mannitol as a sweetener. In this study was concluded that the fast dissolving sublingual film of Benidipine Hydrochloride showed a better result as compared to the marketed formulation and all the parameters showed acceptable results.

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Mayank Sahu, Ankit Anchliya, Bhavana Sahu, Kapil Sahu, & Damini Sahu (January-2023). Formulation and Evaluation of Fast Dissolving Sublingual Film of Benidipine Hydrochloride for the Treatment of Hypertension. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(1), d431-d440. https://ijnrd.org/papers/IJNRD2301351.pdf

Volume 8 Issue 1, January-2023

Pages : d431-d440

Paper Reg. ID: IJNRD_186808

Published Paper Id: IJNRD2301351

Research Area: Engineering

Author Type: Indian Author

Country: Indore, Madhya Pradesh, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2301351.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2301351

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

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