A study on drug utilization pattern and possible drug - drug interactions amoung patients with chronic obstructive pulmonary disease in a tertiary care hospital

A study on drug utilization pattern and possible drug - drug interactions amoung patients with chronic obstructive pulmonary disease in a tertiary care hospital

Registration ID: IJNRD_226634

Published ID: IJNRDTH00186

DOI: http://doi.one/10.1729/Journal.41126

Dheeraj Kumar Bhakat , Archa S Kumar , Kabilan R , Prithvika Wagle

Drug utilisation Pattern, COPD, Drug-drug interactions.

Introduction: Drug Utilization studies is the strongest tool for promoting rational use of drugs in the society. Drug utilization studies help to update clinical medicine. The mortality and morbidity rate are high in COPD patients. In this field there is lack of Drug utilization study. In this study we made an attempt to assess the current prescribing pattern with the WHO prescribing indicators to check whether the prescription pattern followed WHO guidelines and also, we assessed the possible drug-drug interactions in drugs used in the COPD treatment. Methods: A retrospective observational analysis of 300 patients who was admitted in general medicine and pulmonary department was done over a period of 6 months, we recorded the cases from 2016 January to 2020 September and those who met the inclusion criteria. The study was carried out at Sagar Hospital, Kumaraswamy layout, Bengaluru. Drug-Drug interactions were analysed using Lexicomp software. The prescription was analysed using descriptive statistics and the results were expressed in percentage. Results: Out of 300 patients, 102 (34 %) were female and 198 (66%) were found to be male. Majority of patients (42.3%) were above the age of 70 and the least (2.3 %) was found to be below the age of 40. The majority of patients (31%) had only one comorbid condition. Total number of COPD drugs prescribed was found to be 1554. Most frequently used class of drug was short acting beta 2 agonist (90.3%), followed by inhaled corticosteroids (87%), antibiotics (85.6%), short acting muscarinic antagonist (74.6%). Most of the drugs were prescribed by brand name and only 5.4% were prescribed by generic name. The percentage of drugs prescribed from WHO EDL was 49.4%. We found out a total number of 135 drug-drug interactions, in that 59% was found to be Pharmacodynamic interactions and 41 % to be Pharmacokinetic interactions. The severity assessment of DDIs in our study showed that most of interactions were moderate 117(86.6%) followed by major 15(11.2%) and minor 3(2.2%) interactions. Conclusions: This study concludes that prescribing patterns did not follow WHO core prescribing indicators with polypharmacy being common, the concept of generic name prescribing was negligible and reduced prescription from WHO-EDL. Before prescribing medicines, using computer-assisted drug interaction software can help us discover these potential drug-drug interactions, which can assist us to detect and prevent DDI.

Published Paper   E-Certificate

"A study on drug utilization pattern and possible drug - drug interactions amoung patients with chronic obstructive pulmonary disease in a tertiary care hospital ", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.9, Issue 8, page no.141-242, August-2024, Available :https://ijnrd.org/papers/IJNRDTH00186.pdf

Volume 9 Issue 8, August-2024

Pages : 141-242

Paper Reg. ID: IJNRD_226634

Published Paper Id: IJNRDTH00186

Downloads: 000121208

Research Area: Medical Science

Country: Dehradun, Uttarakhand, India

Published Paper PDF: https://ijnrd.org/papers/IJNRDTH00186.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRDTH00186

DOI: http://doi.one/10.1729/Journal.41126

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJNRD (IJ Publication) Janvi Wave

This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition

Call For Paper - Volume 10 | Issue 8 | August 2025

IJNRD is Scholarly open access journals, Peer-reviewed, and Refereed Journals, High Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool), Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) with Open-Access Publications.

INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (IJNRD) aims to explore advances in research pertaining to applied, theoretical and experimental Technological studies. The goal is to promote scientific information interchange between researchers, developers, engineers, students, and practitioners working in and around the world. IJNRD will provide an opportunity for practitioners and educators of engineering field to exchange research evidence, models of best practice and innovative ideas.

Indexing In Google Scholar, SSRN, ResearcherID-Publons, Semantic Scholar | AI-Powered Research Tool, Microsoft Academic, Academia.edu, arXiv.org, Research Gate, CiteSeerX, ResearcherID Thomson Reuters, Mendeley : reference manager, DocStoc, ISSUU, Scribd, and many more

How to submit the paper?

Important Dates for Current issue

Paper Submission Open For: August 2025

Current Issue: Volume 10 | Issue 8

Last Date for Paper Submission: Till 31-Aug-2025

Notification of Review Result: Within 1-2 Days after Submitting paper.

Publication of Paper: Within 01-02 Days after Submititng documents.

Frequency: Monthly (12 issue Annually).

Journal Type: International Peer-reviewed, Refereed, and Open Access Journal.

Subject Category: Research Area