Paper Title
FORMULATION, DEVELOPMENT AND EVALUATION OF in-situ FLOATING GEL OF PREGABALIN
Article Identifiers
Authors
DR.B.V RAMANA , P.CHAITANYA , B.BALA KRISHNA , N.DINESH , B.MD. THOWSIF
Keywords
FORMULATION, DEVELOPMENT AND EVALUATION OF in-situ FLOATING GEL OF PREGABALIN
Abstract
Pregabalin (PRG), an analogue of gamma-aminobutyric acid, reduces the release of many neurotransmitters, including glutamate, and noradrenaline. It is used for the treatment of epilepsy; simple and complex partial convulsion. The present research work aims to ensure a high drug absorption by retarding the advancement of PRG formulation through the gastrointestinal tract. The work aims to design a controlled release PRG formulation which is administered as liquid and further gels in the stomach and floats in gastric juice. Materials and Methods: In situ gelling formulations were prepared using sodium alginate, calcium carbonate, sodium Bicarbonate, hydroxypropyl methylcellulose (HPMC) E-50M, and sodium bicarbonate. The prepared formulations were evaluated for solution viscosity, drug content, in vitro gelling studies, gel strength, and in vitro drug release. Results: The formulation containing 3% w/v sodium alginate and 0.6% w/v HPMC E-50 were considered optimum since it showed minimum floating lag time (18 s), optimum viscosity (287.3 cps). The optimized formulation follows first ordering Higuchi kinetic model with regression value 0.4767 representing diffusion mechanism of drug release. Conclusion: Floating in situ gelling system of PRG can be formulated using sodium alginate as a gelling polymer and calcium carbonate as a complexing agent to control the drug release for about 8 h for the treatment of epilepsy.
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How To Cite (APA)
DR.B.V RAMANA, P.CHAITANYA, B.BALA KRISHNA, N.DINESH, & B.MD. THOWSIF (April-2024). FORMULATION, DEVELOPMENT AND EVALUATION OF in-situ FLOATING GEL OF PREGABALIN. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(4), 865-914. https://ijnrd.org/papers/IJNRDTH00135.pdf
Issue
Volume 9 Issue 4, April-2024
Pages : 865-914
Other Publication Details
Paper Reg. ID: IJNRD_219558
Published Paper Id: IJNRDTH00135
Downloads: 000121989
Research Area: Engineering
Country: -, -, India
Published Paper PDF: https://ijnrd.org/papers/IJNRDTH00135.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRDTH00135
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Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)
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