Paper Title
A REVIEW ON: ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC AND RP-HPLC METHODS FOR THE SIMULTANEOUS ESTIMATION OF VALSARTAN AND HYDROCHLOROTHIAZIDE IN BULK DRUG AND PHARMACEUTICAL DOSAGE FORMS
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Registration ID: IJNRD_328843
Published ID: IJNRD2610045
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Abstract
ABSTRACT Valsartan and hydrochlorothiazide are commonly used together for the treatment of hypertension. Valsartan is an angiotensin II receptor blocker that reduces vasoconstriction and aldosterone-related sodium retention, while hydrochlorothiazide is a thiazide diuretic that promotes the excretion of sodium and water. Their combined action provides an effective antihypertensive effect and the combination is available in various pharmaceutical dosage forms. Therefore, reliable analytical methods are required for the identification, estimation, quality control, and validation of these drugs. This review summarizes the reported analytical methods for the simultaneous estimation of valsartan and hydrochlorothiazide, with special emphasis on UV-visible spectrophotometric and reversed-phase high-performance liquid chromatographic (RP-HPLC) methods. Different spectrophotometric techniques, including simultaneous-equation, first-derivative, absorbance-ratio, and other multicomponent methods, have been reported. RP-HPLC methods have been developed using different reversed-phase columns, aqueous buffers, organic solvents, and UV detection wavelengths. Important validation parameters such as linearity, accuracy, precision, specificity, robustness, limit of detection, and limit of quantification are discussed. UV spectrophotometric methods are generally simple, rapid, economical, and suitable for routine analysis. RP-HPLC methods provide better separation and selectivity, particularly in the presence of formulation excipients and other interfering substances. This review provides a concise summary of reported analytical methods and serves as a useful reference for the development and validation of methods for valsartan and hydrochlorothiazide in bulk drugs and pharmaceutical dosage forms. Keywords: Valsartan, Hydrochlorothiazide, UV spectrophotometry, RP-HPLC, Method Development and Validation.
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Sethupathi.R (October-2026). A REVIEW ON: ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC AND RP-HPLC METHODS FOR THE SIMULTANEOUS ESTIMATION OF VALSARTAN AND HYDROCHLOROTHIAZIDE IN BULK DRUG AND PHARMACEUTICAL DOSAGE FORMS. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 11(10), a388-a404. https://ijnrd.org/papers/IJNRD2610045.pdf
Issue
Volume 11 Issue 10, October-2026
Pages : a388-a404
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Paper Reg. ID: IJNRD_328843
Published Paper Id: IJNRD2610045
Research Area: Pharmacy All
Author Type: Indian Author
Country: Kalasapakkam Taluk, Tiruvannamalai District, Tamil Nadu, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2610045.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2610045
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