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Paper Title

EARLY WARNING SCORE–GUIDED PREDICTION OF CLINICAL DETERIORATION AND MORTALITY IN CRITICALLY ILL PATIENTS

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Registration ID: IJNRD_328783

Published ID: IJNRD2610038

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Keywords

Early warning score; NEWS2; clinical deterioration; critically ill patients; in-hospital mortality; risk stratification; prospective observational study

Abstract

Background: Failure to recognise clinical deterioration in a timely manner remains a preventable contributor to adverse outcomes among hospitalised patients. Track-and-trigger early warning scores (EWS) such as the National Early Warning Score 2 (NEWS2) are widely recommended, but prospective evidence from critical-care and high-dependency settings outside high-income countries remains limited. Methods: In this prospective observational study, 200 consecutive adult patients admitted to the critical care/high-dependency unit of a tertiary-care teaching hospital had an admission NEWS2 score calculated within one hour of admission. Patients were followed to hospital discharge or death for the co-primary outcomes of clinical deterioration within 48 hours (a composite of unplanned ICU transfer, rapid-response activation or cardiac arrest) and in-hospital mortality. Discriminative performance was assessed by the area under the receiver-operating-characteristic curve (AUROC), and independent predictors of mortality were identified by multivariable logistic regression. Results: Overall in-hospital mortality was 12.0% (24/200) and 48-hour deterioration occurred in 21.5% (43/200). Mortality rose from 3.3% in the low-risk band (NEWS2 0–4) to 20.0% in the medium-risk band (5–6) and 30.2% in the high-risk band (≥7) (χ² = 24.44, p < 0.001). NEWS2 discriminated in-hospital mortality with an AUROC of 0.82 (95% CI 0.73–0.90) and 48-hour deterioration with an AUROC of 0.87 (95% CI 0.82–0.92). On multivariable analysis, each one-point increment in admission NEWS2 was independently associated with mortality (adjusted odds ratio 1.53, 95% CI 1.24–1.88, p < 0.001), independent of age and comorbidity burden. Conclusion: An admission NEWS2 score obtained at the bedside provided good discrimination for both short-term deterioration and in-hospital mortality in a critically ill cohort, supporting its use as a low-cost triage and rapid-response trigger tool in resource-limited critical care settings.

How To Cite (APA)

Vellaiyan. T, Aadesh R Desai, Roshini. A, & Madhu mathi D (October-2026). EARLY WARNING SCORE–GUIDED PREDICTION OF CLINICAL DETERIORATION AND MORTALITY IN CRITICALLY ILL PATIENTS. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 11(10), a336-a343. https://ijnrd.org/papers/IJNRD2610038.pdf

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Other Publication Details

Paper Reg. ID: IJNRD_328783

Published Paper Id: IJNRD2610038

Research Area: Health Science All

Author Type: Indian Author

Country: BANGALORE, Karnataka, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2610038.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2610038

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Publication Timeline

Paper Submission
27-09-2026
Peer Review
Through Scholar9.com Platform
Paper Acceptance
03-10-2026
Paper Publication
08-10-2026

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