Paper Title
A REVIEW ON GRIGNARD FUNCTIONALISATION OF CHALCONES : A PLATFORM FOR BIO ACTIVE MOLECULE DISCOVERY
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Registration ID: IJNRD_328032
Published ID: IJNRD2609049
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Keywords
Grignard reagent, Organo magnesium halides, Victor Grignard, alkyl/aryl halides + halides + magnesium metal
Abstract
Grignard reagents are organo magnesium halides with its general formula R-Mg-X are cornerstone reagents in organic synthesis. It was discovered by victor Grignard in 1900 and recognized with the Nobel Prize in the year 1912, they are typically generated by reacting alkyl or aryl halides with magnesium metal in anhydrous ethereal solvents such as diethyl ether and tetrahydrofuran. The carbon-magnesium bond is highly polarized, giving Grignard reagents strong nucleophillic and basic character. This property makes them invaluable for carbon-carbon bond formation, particularly in the synthesis of alcohols and other functionalized organic compounds. Due to their high reactivity towards protic substances like water, alcohols, and amines, these reagents must be handled under strictly anhydrous conditions to prevent decomposition. This study explores chalcones, naturally occurring alpha, beta -unsaturated ketones that form the C6 – C3 - C6 – core of the flavonoids family. The chalcones are widely distributed in plants and contribute to plant growth and defense. They are recognized for diverse pharmacological properties, including anti inflammatory, anti cancer, antioxidant, and antimicrobial activities. Structural modifications like incorporation of thiophene rings enhance their electronic and the biological properties
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How To Cite (APA)
T.Sesharao, Bindu Dwarampudi, Dr.V.Bhaskhar raju, K.Manaswi, K.Sahithi, Sk.Hafeeza, & SK.Thaslima (September-2026). A REVIEW ON GRIGNARD FUNCTIONALISATION OF CHALCONES : A PLATFORM FOR BIO ACTIVE MOLECULE DISCOVERY. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 11(9), a492-a508. https://ijnrd.org/papers/IJNRD2609049.pdf
Issue
Volume 11 Issue 9, September-2026
Pages : a492-a508
Other Publication Details
Paper Reg. ID: IJNRD_328032
Published Paper Id: IJNRD2609049
Research Area: Pharmacy All
Author Type: Indian Author
Country: Pedatadepalli, Tadepalligudem, Andhra Pradesh, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2609049.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2609049
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