Paper Title
A Review on Peptide-Mediated Strategies for the Treatment of Central Nervous System Disorders
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Registration ID: IJNRD_327486
Published ID: IJNRD2608122
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Keywords
Peptides Drug delivery Nanoparticles Nanotechnology Blood–brain barrier CNS diseases Activity-dependent neuro protective protein (ADNP), Alzheimer's disease, Davunetide, NAP, neurodegenerative diseases, neurological disorders.
Abstract
the therapeutic potential of peptides in treating various central nervous system (CNS) disorders and their promising future clinical applications.Actually, peptides are considered the new generation of biologically active tools because they are key regulators in cellular and intercellular physiological responses, which possess enormous potential for the treatment of various diseases Despite their therapeutic potential, peptide drugs face challenges such as poor bioavailability, low stability, invasive administration, and limited blood–brain barrier penetration, driving the development of stable, controlled-release delivery systems.Considerable efforts have been made to design new drugs based on peptides and recent developments in technology and science have provided the means and opportunity to produce a stable as well as controlled-release form of peptide and protein drugs to combat poorly controlled diseases and to increase patients’ quality of life. A major challenge in this regard, however, is the delivery of peptides over the blood–brain-barrier. This review gives an over view of some strategies used to improve both bioavailability and up take of peptide drugs for delivery into the brain .Indeed ,recent findings suggest that the use of peptides by conjugation to a poler such as nano particles can off ertremendoushope in the treatment of brain disorders. The polymer conjugation improves pharmacokinetics by increasing the molecular mass of proteins and peptides and shielding them from proteolytic enzymes. These new strategies will create new opportunities for the future development of neuro therapeutic drugs. In the present review we have focused our attention on the peptide controlled delivery, summarizing literature reports on the use of peptides and nanotechnology for the treatment and diagnosis of brain disorders. 2011 Elsevier Ltd. All rights reserved.
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How To Cite (APA)
VELANTI.YAMINI KRISHNA, YEPUGANTI.BHAVANI SRIKARI, VEERATHI.ANANTHA LAKSHMI, VEERATHI.MRUDALA, & VASAMSETTY.NITHYA MALLIKA (August-2026). A Review on Peptide-Mediated Strategies for the Treatment of Central Nervous System Disorders . INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 11(8), b203-b214. https://ijnrd.org/papers/IJNRD2608122.pdf
Issue
Volume 11 Issue 8, August-2026
Pages : b203-b214
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Paper Reg. ID: IJNRD_327486
Published Paper Id: IJNRD2608122
Research Area: Pharmacy All
Author Type: Indian Author
Country: EAST GODAVARI DISTRICT, ANDHRA PRADESH, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2608122.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2608122
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