Liquisolid Technology in Drug Delivery: Mechanistic Insights, Formulation Approaches, And Future Perspectives

Registration ID: IJNRD_327501

Published ID: IJNRD2607428

: 1

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Manisha Thakur, Vaishali Sharma, Prerna Thakur, Rahul Sharma

Liquisolid systems, Powdered solution technology, Dissolution enhancement, Non-volatile solvents, Poorly soluble drugs, Bioavailability enhancement

Poor aqueous solubility remains one of the most significant challenges in modern drug development, particularly for orally administered drugs. A large proportion of newly discovered drug candidates exhibit low water solubility, which often results in poor dissolution rate and limited oral bioavailability. Various formulation strategies have been explored to overcome this limitation, including solid dispersions, micronization, lipid-based formulations, and inclusion complexes. Among these approaches, liquisolid technology has emerged as a promising and versatile technique for improving the dissolution behavior of poorly water-soluble drugs. Liquisolid systems are formulated by converting a liquid medication— comprising a drug dissolved or suspended in a nonvolatile solvent—into a dry, free-flowing, and compressible powder using suitable carrier and coating materials. This transformation allows the drug to remain in a solubilized or molecularly dispersed state within the powder matrix, which significantly enhances wetting properties and increases the effective surface area available for dissolution. Consequently, liquisolid formulations often exhibit improved dissolution profiles and enhanced oral bioavailability compared with conventional solid dosage forms. The design of liquisolid systems is supported by a mathematical model based on the flowable liquid retention potential (Φ-value) and liquid load factor (Lf), which allows the prediction of the maximum amount of liquid that can be incorporated into a powder system while maintaining acceptable flow and compressibility properties. This theoretical framework has enabled the rational development of liquisolid formulations and facilitated their application across a wide range of poorly soluble drugs. In addition to dissolution enhancement, liquisolid technology has also been investigated for sustained-release formulations, bioavailability enhancement, and industrial drug delivery applications. Recent research has further expanded the scope of this technique through the development of liquisolid pellets, liquisolid microsystems, and nanotechnology-based liquisolid systems. Despite these advantages, challenges such as high excipient load, scale-up limitations, and stability considerations remain important factors influencing the practical implementation of this technology. This review provides a comprehensive overview of liquisolid technology, including its mechanistic principles, formulation strategies, evaluation methods, and pharmaceutical applications. Furthermore, recent advances, regulatory considerations, and future perspectives of liquisolid drug delivery systems are critically discussed to highlight the potential of this technology in overcoming solubility-related challenges in pharmaceutical development.

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Manisha Thakur, Vaishali Sharma, Prerna Thakur, & Rahul Sharma (July-2026). Liquisolid Technology in Drug Delivery: Mechanistic Insights, Formulation Approaches, And Future Perspectives. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 11(7), e287-e320. 1

Volume 11 Issue 7, July-2026

Pages : e287-e320

Paper Reg. ID: IJNRD_327501

Published Paper Id: IJNRD2607428

Research Area: Pharmacy All

Author Type: Indian Author

Country: Hamirpur, Himachal Pradesh, India

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Crossref DOI: 1

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