Paper Title
A Comprehensive Review on Hydrogel Matrix Systems in Transdermal Drug Delivery: Contemporary Formulation Strategies and Advanced Optimization Technologies
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Registration ID: IJNRD_325824
Published ID: IJNRD2606046
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Keywords
Hydrogel matrix, Transdermal drug delivery, Quality by Design, Response Surface Methodology, Artificial Intelligence, Smart hydrogels.
Abstract
Transdermal drug delivery systems are a new technology of pharmaceutical delivery that represents a significant improvement over traditional patches due to excellent biocompatibility, regulable drug delivery, and skin permeation. This is a literature review of modern development techniques of formulations and his progressive technologies of optimization of hydrogel matrices to use in transdermal development. Essential details such as hydrogel chemistry, classification systems, physicochemical characterization, drug release, and skin penetration enhancement are coherently presented. The modern formulation techniques include the rational choice of polymers, crosslinking techniques, nanotechnology, prodrug technologies, chemical and physical increase of permeability, stimuli-responsive intelligent systems and nanocomposite hydrogels. Highly sophisticated optimization tools such as Quality by Design (QbD) concepts, Design of Experiments (DoE) methods, Response Surface Methodology (RSM), and artificial intelligence/machine learning systems have been widely tested and are proven to be transformative in the systematic formulation development. A variety of clinical applications such as pain control, cardiovascular treatment, hormone replacement, neurological and dermatological utilize therapeutic versatility. Issues related to manufacturing, scale-up, regulatory and quality control plans are covered. The existing constraints such as drug candidate constraints, skin variability, and safety considerations are reviewed critically. The future outlook suggests the integration of personalized medicine, the use of smart wearables, IoT connectivity, sustainable materials, and the new application in gene therapy and vaccine delivery. The review gives pharmaceutical scientists and researchers in depth information that will bridge the basic concepts with the latest optimization technologies to develop rational hydrogel transdermal patches.
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How To Cite (APA)
Omkar Rahane & Dr. Sudarshan Borkar (June-2026). A Comprehensive Review on Hydrogel Matrix Systems in Transdermal Drug Delivery: Contemporary Formulation Strategies and Advanced Optimization Technologies. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 11(6), a384-a406. https://ijnrd.org/papers/IJNRD2606046.pdf
Issue
Volume 11 Issue 6, June-2026
Pages : a384-a406
Other Publication Details
Paper Reg. ID: IJNRD_325824
Published Paper Id: IJNRD2606046
Research Area: Pharmacy All
Author Type: Indian Author
Country: Ahmednagar, Maharashtra, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2606046.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2606046
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