Paper Title
FORMULATION AND EVALUATION OF CIMETIDINE FAST DISSOLVING ORAL FILM USING NOVEL POLYMERS
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Registration ID: IJNRD_324563
Published ID: IJNRD2605231
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Keywords
H2 receptor anatgonist, GERD, Surface pH, Cimetidine, Oral Films, Pullulan
Abstract
Cimetidine, a histamine H2-receptor antagonist, is widely used for the treatment of peptic ulcers and gastroesophageal reflux disease (GERD). Conventional oral dosage forms often face challenges such as delayed onset of action, poor patient compliance, and difficulty in swallowing, especially among pediatric and geriatric patients. To overcome these limitations, this study focuses on the formulation and evaluation of fast-dissolving oral film patches of cimetidine using novel film-forming polymers.The objective was to develop a patient-friendly, fast-releasing dosage form that dissolves rapidly in the oral cavity without the need for water. Novel polymers such as pullulan, hydroxypropyl methylcellulose (HPMC), and natural alternatives like pectin and sodium alginate were investigated for their film-forming ability, mechanical strength, and disintegration properties. The films were prepared using the solvent casting technique and optimized based on physicochemical parameters including thickness, folding endurance, surface pH, tensile strength, disintegration time, drug content uniformity, and in vitro drug release profile. The optimized formulation showed a disintegration time of less than 30 seconds and released more than 85% of the drug with in 5 minutes ,indicating rapid onset of action. The study concludes that oral film patches of cimetidine formulated with novel polymers offer a promising alternative to conventional oral dosage forms ,enhancing therapeutic efficacy and patient compliance
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How To Cite (APA)
Navya Manavala, N. Priyanka, Manoj kumar, Dr. Tripuramallu Rajithasree, & Dr. Chandrasekhara Rao Baru (May-2026). FORMULATION AND EVALUATION OF CIMETIDINE FAST DISSOLVING ORAL FILM USING NOVEL POLYMERS . INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 11(5), c300-c309. https://ijnrd.org/papers/IJNRD2605231.pdf
Issue
Volume 11 Issue 5, May-2026
Pages : c300-c309
Other Publication Details
Paper Reg. ID: IJNRD_324563
Published Paper Id: IJNRD2605231
Research Area: Pharmacy All
Author Type: Indian Author
Country: Hyderabad, Telangana, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2605231.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2605231
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