Paper Title
A study to compare the effectiveness of povidone Iodine mouthwash vs Chlorhexidine mouthwash among cancer patients.
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Registration ID: IJNRD_312574
Published ID: IJNRD2602159
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Keywords
Cancer, Povidone iodine and Chlorhexidine mouthwash.
Abstract
ABSTRACT Background: Cancer continues to be one of the leading causes of morbidity and mortality across the globe. Advances in cancer treatment—such as surgery, radiotherapy, chemotherapy, targeted therapy, and immunotherapy—have significantly improved survival rates, yet these treatments often lead to a range of adverse effects. Among them, oral complications are some of the most common and debilitating, especially in patients undergoing chemotherapy and radiotherapy. Chlorhexidine mouthwash is widely used as a standard oral antiseptic due to its broad-spectrum antimicrobial properties. However, its side effects—such as tooth discoloration, altered taste, mucosal irritation, and reduced patient acceptance—limit its long term use. Povidone iodine, another commonly used antiseptic agent, offers broad antiviral, antibacterial, and antifungal activity and may be a suitable alternative, particularly for immunocompromised patients. However, the studies related to the effectiveness of chlorhexidine mouthwash vs povidone iodine mouthwash are limited. Materials and Methods: A randomized controlled trial (RCT) was conducted to compare the effectiveness of chlorhexidine and povidone iodine mouthwash in cancer patients undergoing chemotherapy and/or radiotherapy. A prospective observational study was conducted among cancer subjects who underwent radiation or chemotherapy in Apollo Hospitals International Limited, Gandhinagar. Fifty cancer patients were selected by purposive sampling technique. The patients were aged in the range of 25 to above 65 years. The WHO oral care assessment tool was adopted to assess the severity of mucositis and other oral complications. 10ml of diluted povidone iodine mouthwash was given to experimental group I, while 10 ml of diluted chlorhexidine mouthwash was given to group II. Using the WHO Oral Assessment Tool, the level of oral complications in groups I and II was evaluated on the first, third, and fifth days. Results: Fifty cancer patients’ results were analyzed, and it shows that out of 50 patients, patients between the ages of 40-65 (62%) were receiving chemotherapy. Experimental group 1 showed a mild level of mucositis. Whereas experimental group 2 demonstrated a moderate level of mucositis on the 5th day. The results of the study indicate that povidone iodine solution was significantly reducing oral complications compared to chlorhexidine solution. Conclusion: In the present study, it was observed that both mouthwashes were individually effective on oral complications, but the comparison revealed that povidone iodine mouthwash was more effective than chlorhexidine mouthwash at reducing complications.
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How To Cite (APA)
Ms. Preeti D Talpada & Mr.Sanjay Purohit (February-2026). A study to compare the effectiveness of povidone Iodine mouthwash vs Chlorhexidine mouthwash among cancer patients.. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 11(2), b488-b494. https://ijnrd.org/papers/IJNRD2602159.pdf
Issue
Volume 11 Issue 2, February-2026
Pages : b488-b494
Other Publication Details
Paper Reg. ID: IJNRD_312574
Published Paper Id: IJNRD2602159
Research Area: Health Science All
Author Type: Indian Author
Country: Gandhinagar, Gujarat, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2602159.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2602159
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