PhytochemicaI-Based Topical Hydrogels Incorporating Essential Oils for the treatment and management of Gas Gangrene: A Critical Review

Registration ID: IJNRD_312239

Published ID: IJNRD2602128

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Hritik, Dr. Puneet Kumar

Gas gangrene; Clostridium perfringens; Clostridium septicum;Essential oils; Phytochemicals;

Gas gangrene is a rapidly progressive, life-threatening necrotizing infection predominantly caused by anaerobic Clostridium species, notably Clostridium perfringens and Clostridium septicum. Despite advances in surgical intervention, antibiotic therapy, and supportive care, the morbidity and mortality associated with gas gangrene remain high, particularly in immunocompromised individuals and patients with traumatic or ischemic wounds. The increasing concern over antimicrobial resistance, limited tissue penetration of systemic antibiotics in necrotic environments, and the aggressive toxin-mediated pathology of Clostridium species have prompted the exploration of alternative and adjunctive therapeutic strategies. In this context, phytochemical-based topical hydrogels incorporating essential oils have emerged as promising localized treatment platforms for anaerobic wound infections. Essential oils derived from medicinal plants exhibit broad-spectrum antimicrobial, antiinflammatory, antioxidant, and wound-healing properties, while hydrogel matrices provide an ideal delivery system due to their biocompatibility, moisture retention, and controlled release capabilities. This critical review comprehensively examines the pathophysiology of gas gangrene, the microbiological characteristics of causative Clostridium species, and the therapeutic limitations of current treatment modalities. It further explores the antimicrobial mechanisms of essential oils against anaerobic pathogens, the formulation rationale of topical hydrogel systems, and existing evidence supporting their potential role in gas gangrene management. Challenges, safety considerations, and future research directions are also discussed to highlight the translational prospects of phytochemical-based topical hydrogels in managing this severe and devastating condition.

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Hritik & Dr. Puneet Kumar (February-2026). PhytochemicaI-Based Topical Hydrogels Incorporating Essential Oils for the treatment and management of Gas Gangrene: A Critical Review . INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 11(2), b219-b238. https://ijnrd.org/papers/IJNRD2602128.pdf

Volume 11 Issue 2, February-2026

Pages : b219-b238

Paper Reg. ID: IJNRD_312239

Published Paper Id: IJNRD2602128

Research Area: Pharmacy All

Author Type: Indian Author

Country: Sundernagar, Himachal Pradesh, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2602128.pdf

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