Paper Title
Nasopharyngeal Angiofibroma: A 34 - Year Retrospective Review from a Single Institution
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Registration ID: IJNRD_312134
Published ID: IJNRD2601324
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Keywords
Juvenile nasopharyngeal angiofibroma; nasopharynx; endoscopic endonasal surgery; lateral rhinotomy; transpalatal approach; embolization; radiotherapy; recurrence.
Abstract
Background: Juvenile nasopharyngeal angiofibroma (JNA) is a rare, histologically benign but locally aggressive vascular tumor, classically affecting adolescent males and presenting with nasal obstruction and recurrent epistaxis. This study summarizes a large single-institution experience over three decades in a high-volume tertiary ENT center. Materials and Methods: A retrospective review was performed of 364 histologically confirmed cases of nasopharyngeal angiofibroma treated at Government ENT Hospital, Hyderabad, India, over 34 years (1980–2014). Medical records were analyzed for demographics, clinical presentation, radiologic evaluation, staging (Radkowski system), operative approach, blood loss/transfusion requirements, duration of hospitalization, complications, recurrence, radiotherapy use, and mortality. Results: Age at diagnosis ranged from 7–50 years (mean 18 years). Most patients were in the 11–20-year age group (292/364; 80.22%). Surgical excision was the primary treatment in 98.88% of cases, with approaches including lateral rhinotomy (140; 38.46%), transpalatal (117; 32.14%), combined transpalatal + lateral rhinotomy (55; 15.11%), endoscopic endonasal (31; 8.52%), and Weber–Ferguson (20; 5.49%). Endoscopic resections increased after 2000. Estimated blood loss was lower with endoscopic surgery (~300–350 mL) compared with open approaches (~1250–2000 mL), with shorter hospitalization (4 days vs 7–10 days) and fewer complications. Primary radiotherapy was used in 2 patients due to extensive intracranial extension; postoperative radiotherapy was used selectively for residual intracranial disease/intractable bleeding. Overall recurrence was most commonly seen within the first postoperative year; outcomes improved with adoption of endoscopic techniques in later years. Overall mortality was primarily related to severe perioperative or postoperative hemorrhage. Conclusion: Surgery remains the gold standard for JNA. Over time, a clear institutional trend toward endoscopic endonasal resection was associated with reduced blood loss, fewer complications, shorter hospital stay, and improved disease control in appropriately selected stages. Careful preoperative staging and meticulous skull base clearance are critical to minimize recurrence.
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How To Cite (APA)
Vishnu Vardhan Reddy Martha (January-2026). Nasopharyngeal Angiofibroma: A 34 - Year Retrospective Review from a Single Institution . INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 11(1), d174-d187. https://ijnrd.org/papers/IJNRD2601324.pdf
Issue
Volume 11 Issue 1, January-2026
Pages : d174-d187
Other Publication Details
Paper Reg. ID: IJNRD_312134
Published Paper Id: IJNRD2601324
Research Area: Medical Science All
Author Type: Indian Author
Country: Cumming, GA, United States
Published Paper PDF: https://ijnrd.org/papers/IJNRD2601324.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2601324
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