Sustained-Release Mucoadhesive Microspheres for Gastric Retention: Formulation Strategies Using Natural Polysaccharides and Synthetic Polymers

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Published ID: IJNRD2601285

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Pooja Anjali, Dr. Puneet Kumar

Mucoadhesive microspheres; Gastroretentive drug delivery; Sustained release; Natural polysaccharides; Synthetic polymers

Sustained-release mucoadhesive microspheres have emerged as a promising gastroretentive drug delivery strategy to overcome the limitations associated with conventional oral dosage forms, particularly short gastric residence time and variable drug absorption. These systems are designed to adhere to the gastric mucosal surface, thereby prolonging residence in the stomach and enabling controlled drug release at the desired site. The present review provides a comprehensive overview of sustained-release mucoadhesive microspheres developed for gastric retention, with a particular focus on formulation strategies employing natural polysaccharides and synthetic polymers. The physiological basis of gastric retention and the fundamental mechanisms of mucoadhesion are discussed to establish the rationale for system design. Emphasis is placed on the role of polymer selection, highlighting the complementary advantages of natural polysaccharides, such as biocompatibility and strong mucoadhesive properties, and synthetic polymers, which offer reproducibility and controlled release characteristics. Various formulation techniques, including ionic gelation, emulsion-based methods, and spray drying, are critically reviewed along with key evaluation parameters used to assess microsphere performance. In addition, in vivo considerations, translational challenges, and regulatory aspects are addressed. Overall, this review consolidates current knowledge and recent advances in mucoadhesive microsphere-based gastroretentive systems and underscores their potential to improve oral drug delivery and therapeutic outcomes.

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Pooja Anjali & Dr. Puneet Kumar (January-2026). Sustained-Release Mucoadhesive Microspheres for Gastric Retention: Formulation Strategies Using Natural Polysaccharides and Synthetic Polymers. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 11(1), c593-c609. https://ijnrd.org/papers/IJNRD2601285.pdf

Volume 11 Issue 1, January-2026

Pages : c593-c609

Paper Reg. ID: IJNRD_312075

Published Paper Id: IJNRD2601285

Research Area: Pharmacy All

Author Type: Indian Author

Country: Sarkaghat, Mandi, Himachal Pradesh, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2601285.pdf

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