Paper Title
EFFECT OF ETHANOLIC EXTRACT OF CARDIA DICHOTMA ON STREPTOZOTOCIN INDUCED DIABETIC CARDIOMYOPATHY IN RATS
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Registration ID: IJNRD_310695
Published ID: IJNRD2511292
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Keywords
Diabetic Cardiomyopathy, Cardia dichotma, DNA alkylation, GLUT2 glucose transporter.
Abstract
Diabetes is a group of metabolic diseases in which a person has high blood sugar, either because the pancreas does not produce enough insulin, or because cells do not respond to the insulin that is produced. This high blood sugar produces the classical symptoms of polyuria (frequent urination), polydipsia (increased thirst) and polyphagia (increased hunger). Diabetes mellitus is a syndrome characterized by hyper-glycaemia and disturbances of carbohydrate, fat and protein metabolism associated with absolute or relative deficiencies in insulin secretion and, or insulin action. About 70-80% of deaths in diabetic patients are due to vascular disease. In particular hyperglycemia, the primary clinical manifestation of diabetes, is thought to contribute to diabetic complications by altering vascular cellular metabolism, vascular matrix molecules and circulating lipoproteins. STZ is a nitrosourea analogue, preferentially uptake by pancreatic beta cells via GLUT2 glucose transporter and causes DNA alkylation followed by the activation of poly ADP ribosylation leading to depletion of cytosolic concentration of NAD+ and ATP. The present study was performed to evaluate the potency and effect of ethanolic extract of Cardia dichotma in diabetic Cardiomyopathy. Thus, it can be concluded from our findings that the levels of Glucose, total, total serum cholesterol, triglycerides, total lipids, VLDL and LDL-cholesterol which are actually raised in diabetic cardiomyopathy can be lowered with ethanolic extract of Cardia dichotma. Level of body wt; total protein, serum albumin, serum globulin, and HDL decreased in diabetes cardiomyopathy can be increased with ethanolic extract of Cardia dichotma. Two doses were given to chosen animal model and dose at 200mg/kg has shown its significant effect. Further studies both on the extract and/or its chemical constituents are needed to pinpoint the findings.
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How To Cite (APA)
JAIN NISHI & SHARMA AKASH (November-2025). EFFECT OF ETHANOLIC EXTRACT OF CARDIA DICHOTMA ON STREPTOZOTOCIN INDUCED DIABETIC CARDIOMYOPATHY IN RATS. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 10(11), d16-d36. https://ijnrd.org/papers/IJNRD2511292.pdf
Issue
Volume 10 Issue 11, November-2025
Pages : d16-d36
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Paper Reg. ID: IJNRD_310695
Published Paper Id: IJNRD2511292
Research Area: Other area not in list
Author Type: Indian Author
Country: -, -, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2511292.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2511292
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