Paper Title
Systems-Based Mechanistic Appraisal of a Polyherbal Complex Targeting Inflammation and Nociception: Integrative Insights into Phytochemical Synergy
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Registration ID: IJNRD_310537
Published ID: IJNRD2511190
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Keywords
Synergy of four herbs-P Boerhaavia diffusa–Leucas aspera–Grewia asiatica–Piper nigrum. bioactive-rich complex, inflammation, nociception, network pharmacology, mechanistic pharmacology.
Abstract
The growing occurrence of inflammatory and nociceptive disorders warrants the investigation of safer, multi-targeted therapies from natural origin resources. This review is devoted to the bioactive-rich polyherbal complex of Boerhaavia diffusa (Punarnava), Leucas aspera, Piper nigrum (Black Pepper), and Grewia asiatica (Phalsa) which is well-documented in folklore and traditional medicine for its anti inflammatory and analgesic properties. Each plant offers a particular phytochemical constituents (alkaloids, flavonoids, phenolics, lignans, terpenoids, and piperine) which in their totality exhibit a synergistic modulation of inflammatory and pain pathways. This review highlights the dual mechanistic interactions of antagonizing COX, LOX, TNF-α, IL-1β mediators and the descending central and peripheral nociceptive pathway opioids, serotonin, and vanilloid systems. Mechanistic elucidations are derived from the body of work from preclinical, molecular docking, and network pharmacology on the NF-κB, MAPK, and Nrf2 pathway crosstalk. Combinatorial phytochemical diversity, systems pharmacology, and mechanistic rationale provide strong basis of the polyherbal complex as anti-inflammatory and antinociceptive medicine. This review calls for more preclinical and translational studies to meticulously develop, authenticate, and clinically adopt this synergistic polyherbal medicine as safe and effective for inflammatory pain management.
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How To Cite (APA)
Mr. Pushkar, Ms. Neha Jain, Dr. Prasoon Kumar Saxena, & Dr. R.D. Gupta (November-2025). Systems-Based Mechanistic Appraisal of a Polyherbal Complex Targeting Inflammation and Nociception: Integrative Insights into Phytochemical Synergy. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 10(11), b784-b802. https://ijnrd.org/papers/IJNRD2511190.pdf
Issue
Volume 10 Issue 11, November-2025
Pages : b784-b802
Other Publication Details
Paper Reg. ID: IJNRD_310537
Published Paper Id: IJNRD2511190
Research Area: Pharmacy All
Author Type: Indian Author
Country: Raebareli, Uttar Pradesh, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2511190.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2511190
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