Paper Title
Synthesis and Characterization of Novel Thiazole derivatives of Pyrrolidino-Disubstituted N-arylmaleimides.
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: Keywords
Keywords: Dibromosccinimide, N,N-dimethylamine, Vilsmeier Haack formylation, thiosemicarbazide, Phenacyl bromide.
Abstract
Abstract: The compound 1 was reacted with bromine in DMF to obtained dibromo succinimide 2. The compound 2 was reacted with pyrrolidine as a base followed by dehydrohalogenation to obtained monobromo compound 3 through common enaminone intermediate, further compound 3 on Vilsmeier Haack formylation afforded compound 4 with good yield. The condensation of 2,5-dihydro-2,5-dioxo-1-phenyl-4-(pyrrolidin-1-yl)-1H-pyrrole-3-carbaldehyde 4 with thiosemicarbazide hydrochloride in ethanol in presence of acetic acid furnished compound 5 with 81 % yield. The compound 5 react with disubstituted phenacyl bromide 6 a-d to obtained thiazole derivative of Di-substituted N-aryl maleimides 7 a-d with good yield. All the synthesized compounds were well characterised by spectral and analytical techniques. Keywords: Dibromosccinimide, N,N-dimethylamine, Vilsmeier Haack formylation, thiosemicarbazide, Phenacyl bromide. *Corresponding Author: Dr. Sunita A. Chaudhari (Patil) Email Id: sunitavasantpatil@gmail.com
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How To Cite (APA)
Dr.Sunita A. Chaudhari (Patil), Vasant M.Patil, Dr.Sambhaji V.Patil, & Dr.Vishwanath R. Patil (October-2025). Synthesis and Characterization of Novel Thiazole derivatives of Pyrrolidino-Disubstituted N-arylmaleimides.. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 10(10), a389-a395. https://ijnrd.org/papers/IJNRD2510046.pdf
Issue
Volume 10 Issue 10, October-2025
Pages : a389-a395
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Paper Reg. ID: IJNRD_309662
Published Paper Id: IJNRD2510046
Downloads: 00026
Research Area: Chemistry All
Author Type: Indian Author
Country: Nagpur, Maharashtra, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2510046.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2510046
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