ROLE OF HER2/NEU OVEREXPRESSION IN DIAGNOSIS AND ITS PROGNOSTIC SIGNIFICANCE IN GASTRIC ADENOCARCINOMA

Registration ID: IJNRD_309069

Published ID: IJNRD2508235

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ABHISHEK SINGH, NISHANT RAMAN, SAMIKSHA SINGH, Shirish salunke

Keywords: Immunohistochemistry, Herceptin, Gastric adenocarcinoma, Trastuzumab

Abstract: Introduction: Gastric cancer is one of the most common tumor and remains the second most common cause of cancer mortality in the world. The mainstay of treatment is the surgical resection and can cure patients at an early stage. The survival rate of patient’s with advance gastric cancers remains poor despite of new treatment strategies such as peri-operative chemotherapy or adjuvant chemoradiation. There are evidence of the role of HER2neu overexpression in gastric adenocarcinoma patient’s and it has correlated with more aggressive course of disease and poor outcomes. HER2neu overexpression in gastric adenocarcinomas is also becoming important due to availability of targeted treatment with trastuzumab chemotherapy have proven effective. Material and Methods: This was a retrospective study in cases of Gastric Adenocarcinoma presenting to a tertiary care hospital over a period of 02 years. A total of 30 cases were included and were subjected for ER, PR & HER2neu receptor study. Results: The correlation studies were performed between Her2neu positivity and type of specimen, tumor histological subtype, tumor location, tumor differentiation, tumor grading, tumor staging, lymphovascular invasion, lymph node metastasis. In our study Her2 overexpression was observed in 13 % cases of gastric carcinoma. Higher HER2neu expression was seen in older age and in males. A positive association between HER2neu positivity and intestinal type cancers was identified along with significant association of HER2neu positivity with proximal tumors. More cases of HER2/neu positivity was seen with poorly differentiated carcinomas. No statistically significant correlation was found between HER2neu overexpression and tumor stage, lymphovascular and perineural invasion in the present study. Conclusion: Her2neu IHC study is become very essential due to availability of trastuzumab drug which increases the significant overall survival in gastric adenocarcinoma. The overall reliability of HER2neu evaluation by IHC can be affected by diverse preanalytical, analytical and post-analytical variables. FISH should be done in all equivocal cases (2+) for increased diagnostic accuracy.

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ABHISHEK SINGH, NISHANT RAMAN, SAMIKSHA SINGH, & Shirish salunke (August-2025). ROLE OF HER2/NEU OVEREXPRESSION IN DIAGNOSIS AND ITS PROGNOSTIC SIGNIFICANCE IN GASTRIC ADENOCARCINOMA. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 10(8), c237-c269. https://ijnrd.org/papers/IJNRD2508235.pdf

Volume 10 Issue 8, August-2025

Pages : c237-c269

Paper Reg. ID: IJNRD_309069

Published Paper Id: IJNRD2508235

Research Area: Humanities All

Author Type: Indian Author

Country: AHMEDABAD, GUJARAT, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2508235.pdf

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