Paper Title
Transdermal Patches, Dissolving microneedle, Fabrication method of TDDS, Applications of TDDS
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Registration ID: IJNRD_307981
Published ID: IJNRD2506322
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Transdermal Patches, Dissolving microneedle, Fabrication method of TDDS, Applications of TDDS
Abstract
Microneedles are an emerging technology for transdermal drug delivery, offering a minimally invasive and efficient alternative to traditional injections and topical formulations. All types of microneedles—solid, hollow, coated, and dissolving—function by penetrating the stratum corneum, creating microchannels that facilitate drug transport. Among these, coated and hollow microneedles have shown success but face challenges such as low drug loading capacity, pore blockage, and complex fabrication processes. In contrast, dissolving microneedles (DMNs) provide enhanced drug loading, simplified fabrication, and improved patient compliance. These microneedles, composed of biodegradable and water-soluble polymers, dissolve completely upon skin penetration, eliminating the risk of needle-stick injuries and biohazardous waste. Additionally, DMNs can be designed to release both small and large biomolecules, including peptides, proteins, and vaccines, ensuring controlled and sustained drug delivery. Notably, some dissolving microneedles can be formulated entirely from the therapeutic agent itself, eliminating the need for additional excipients and enhancing formulation efficiency. This article explores the materials, fabrication techniques, characterization methods, and applications of DMNs, highlighting their potential in vaccination, chronic disease management, and pain-free drug delivery. Furthermore, we discuss the current challenges associated with DMN technology, such as mechanical strength, drug stability, and large-scale manufacturing. Finally, we outline future research directions, emphasizing the role of DMNs in revolutionizing transdermal drug administration.
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How To Cite (APA)
Siddhesh Sunil Tamboli & Gayatri Panigrahi (June-2025). Transdermal Patches, Dissolving microneedle, Fabrication method of TDDS, Applications of TDDS . INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 10(6), d182-d191. https://ijnrd.org/papers/IJNRD2506322.pdf
Issue
Volume 10 Issue 6, June-2025
Pages : d182-d191
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Paper Reg. ID: IJNRD_307981
Published Paper Id: IJNRD2506322
Research Area: Pharmacy All
Author Type: Indian Author
Country: Nashik, Maharashtra, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2506322.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2506322
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