Paper Title
Progeria Syndrome: Unravelling the Mystery of Premature Aging in Children
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Registration ID: IJNRD_302916
Published ID: IJNRD2412254
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Keywords
Progeria, Genetic condition, Biomarkers, HGPS, Lonafarnib
Abstract
Hutchinson- Gilford Progeria Syndrome (HGPS) is a rare genetic condition marked by rapid aging in children, primarily resulting from mutations in the LMNA gene. This review article delves into the clinical manifestations, underlying mechanisms, and prevalence of HGPS, emphasizing common symptoms such as growth delays, hair loss, and cardiovascular issues that often lead to premature death. It further investigates the molecular processes associated with the disorder, focusing on progerin production—an abnormal protein that interferes with cellular operations and accelerates aging. The article also reviews current diagnostic methods, including genetic analyses and imaging findings, alongside ongoing clinical trials exploring potential treatments like Lonafarnib. While there have been notable advancements in research and therapeutic approaches, challenges persist in finding reliable biomarkers and comprehending the full effects of HGPS on those affected. This review seeks to offer a thorough understanding of progeria, highlighting the necessity for ongoing research to enhance diagnostic and treatment options for this challenging condition.
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How To Cite (APA)
PRITAM SINGHA & MD.ASIF IQUEBAL (December-2024). Progeria Syndrome: Unravelling the Mystery of Premature Aging in Children. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(12), c423-c431. https://ijnrd.org/papers/IJNRD2412254.pdf
Issue
Volume 9 Issue 12, December-2024
Pages : c423-c431
Other Publication Details
Paper Reg. ID: IJNRD_302916
Published Paper Id: IJNRD2412254
Research Area: Pharmacy All
Author Type: Indian Author
Country: Vadodara, Gujarat, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2412254.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2412254
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