Paper Title
Formulation and Evaluation of Enteric Coated tablets of Pantoprazole.
Article Identifiers
Registration ID: IJNRD_302861
Published ID: IJNRD2412228
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Keywords
Super disintegrates, HPMC, PVP, Direct compression, Proton pump inhibitor, Cellulose acetate phthalate.
Abstract
Pantoprazole reduces the amount of acid your stomach makes. It's used for heartburn, acid reflux and gastro-oesophageal reflux disease (GORD) – GORD is when you keep getting acid reflux. It's also taken to prevent and treat stomach ulcers. Sometimes, pantoprazole is taken for a rare condition caused by a tumour in the pancreas or gut called Zollinger-Ellison syndrome. It is a proton pump inhibitor, belongs to group of benzimidazole, Pantoprazole sodium were prepared by direct compression method using different concentration of, microcrystalline cellulose as filler, mannitol and dicalcium phosphate as diluents, crosscarmellose sodium as disintegrating agents, magnesium stearate and talc was used as a glidant and lubricant respectively. Direct compression is economic compared to wet granulation since it requires fewer unit operations. The prepared tablets were coated using enteric coating polymer such as cellulose acetate phthalate, Eudragit L100 and by dip coating method. The in vitro release was studied using acidic buffer pH 1.2 and phosphate buffer pH 6.8. Prepared all batch’s C2F9 was found best, with hardness 5.60 ± 0.24 (Kg/cm2), drug content 99.08 ± 0.35(%), disintegration time 7.02± 0.21(min), and percentage cumulative drug released which started after 120 min and reached 99.72 after 180 min. Stability studies indicated that the developed tablets were stable and retained their pharmaceutical properties at room temperature and 40 °C / 75% RH for a period of 3 months.
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How To Cite (APA)
Shikha Jaiswal, Dr. Govind Nayak, & Mrs. Payal Saiju (December-2024). Formulation and Evaluation of Enteric Coated tablets of Pantoprazole.. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(12), c220-c239. https://ijnrd.org/papers/IJNRD2412228.pdf
Issue
Volume 9 Issue 12, December-2024
Pages : c220-c239
Other Publication Details
Paper Reg. ID: IJNRD_302861
Published Paper Id: IJNRD2412228
Research Area: Pharmacy All
Author Type: Indian Author
Country: KOREA, CHHATTISGARH, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2412228.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2412228
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