Paper Title
FABRICATION AND EVALUATION OF GLIMEPIRIDE
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Registration ID: IJNRD_302441
Published ID: IJNRD2412094
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Keywords
Glimepiride, Nano suspension,Density, Viscosity, PH, Particle size, Zeta potential, and Diffusion studies.
Abstract
Nano suspension is a part of nanotechnology which is a submicron colloidal dispersion of pharmaceutical active ingredients in a liquid phase having size range below 1 um, and which is stabilized by surfactants and polymers. Most of the newly developed drugs are water insoluble, shows poor bioavailability. Glimepiride is an anti-diabetic drug belongs to sulfonylurea class, which is used to treat type II diabetes mellitus. Glimepiride increases the insulin secretion by acting on β-cells of the pancreas. Glimepiride binds to sulphonylurea receptors which are present on β-cell on the plasma membrane, which close the ATP-sensitive potassium channel leading to depolarization of cell membrane. So there is the opening of voltage-gated calcium channel due to which there is an influx of calcium ions causes secretion of the preformed insulin molecule. It is categorized under biopharmaceutical classification system class II drug, having poor solubility and high permeability. The present study is done on glimepiride nanosuspension.The major problem with the drug is having poor solubility when given through oral route. To overcome this problem it is formulated as Nano suspension by using the best solvent like acetone by solvent evaporation method. The prepared glimepiride Nano suspension was evaluated for Density, Viscosity, PH, Particle size, Zeta potential, and Diffusion studies. Among all the formulations of glimepiride, F4 formulation shows maximum drug release at the end of 12 hrs. (98%).
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How To Cite (APA)
Dr AVS Madhulatha, R.Esther Manasa, & Ch. Suresh (December-2024). FABRICATION AND EVALUATION OF GLIMEPIRIDE. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(12), a867-a885. https://ijnrd.org/papers/IJNRD2412094.pdf
Issue
Volume 9 Issue 12, December-2024
Pages : a867-a885
Other Publication Details
Paper Reg. ID: IJNRD_302441
Published Paper Id: IJNRD2412094
Research Area: Science and Technology
Author Type: Indian Author
Country: -, -, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2412094.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2412094
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