Computational, biochemical and genomic analyses for a novel gene on human chromosome 12, C12ORF24 and structural analyses of its cognate protein, FAM216A.

Registration ID: IJNRD_300246

Published ID: IJNRD2409074

: http://doi.one/10.1729/Journal.41529

About Hard Copy and Transparent Peer Review Report

Vishnupriya J

Chromosome 12 open reading frame 24(C12ORF24), Family with sequence similarity 216, member A(FAM216A),Basic Local Alignment Search Tool for -Nucleotide and –Protein(BLAST-N&-P),GPN-loop gtpase 3(GPN3),Expert Protein Analysis System(ExPASy), Search Tool for the Retrieval of Interacting Genes/Proteins (STRING db),Signal peptide site(Sp site).

The Human Genome Project was initiated to completely sequence our genome there still remain “uncharacterized crucial genes” in different chromosomes , under genetic changes lead to cancer prone diseases, solid tumors, leukemia, etc. This study represents a brief analysis particularly on chromosome 12 Open Reading Frame 24. The gene named as C12ORF24 and its novel protein as FAM216A, which is at the cytogenetic location q24.11.The C12ORF24 gene sequence retrived from the NCBI database and the BLAST (-N &-P) analysis performed within the species and also between the ortholog gene species. BLASTN result shows 100% nucleotide sequence similarity of Human gene C12ORF24 with the Human GPN3 transcript (reverse) and the genomic sequence of alternate assembly of Human C1 1.1. And shows 77% similarity over the species rat (C12) and mouse (C5) containing homolog gene. Likewise the amino acid sequence of human C12ORF24 compared with that of rat and mice showed 68% similarity in rat and 85% similarity in mice. So humans and mice , two species separated by more than million years of evolutionary history, have similar genes. Further Human gene study about the exon/intron organization revealed that three species containing homolog gene C12ORF24 has 7 exons and 6 introns and TSS, Poly(A) signal site, UTR’s(5’&3’), epigenetics -were annotated using the respective public database tools. The cognate protein (FAM216A) study revealed about its post –translational modification sites especially phosphorylation which determines its functional state of activity via ExPASy; its primary and secondary structure was predicted and compared with that of rat and mice having homolog protein. Tissue distribution inferred from the whole human proteome project also revealed a prominent existence of FAM216A protein in brain and testis, thereby connecting psychiatric and hormone related functions. The STRING db extensive protein – protein interactions results has shown that FAM216A protein interacts with Ubiquitin, suggesting that its action may be pivotal in determining brain function(s).This pivotal information will certainly increase our future knowledge on this human gene and may lead to the development of novel treatment modalities in this genomic era.

Published Paper   E-Certificate

Vishnupriya J (September-2024). Computational, biochemical and genomic analyses for a novel gene on human chromosome 12, C12ORF24 and structural analyses of its cognate protein, FAM216A.. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(9), a662-a680. http://doi.one/10.1729/Journal.41529

Volume 9 Issue 9, September-2024

Pages : a662-a680

Paper Reg. ID: IJNRD_300246

Published Paper Id: IJNRD2409074

Research Area: Life Sciences All

Author Type: Indian Author

Country: chennai / thiruvalluvar district, Tamilnadhu, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2409074.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2409074

Crossref DOI: http://doi.one/10.1729/Journal.41529

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

UGC CARE JOURNAL PUBLICATION | ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

An International UGC CARE JOURNAL PUBLICATION, Low Cost, Scholarly Open Access, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJNRD (IJ Publication) Janvi Wave | IJNRD.ORG | IJNRD.COM | IJPUB.ORG

© 2026 - Authors hold the copyright of this article. This work is licensed under a Creative Commons Attribution 4.0 International License. and The Open Definition. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0). 🛡️ Disclaimer: The content, data, and findings in this article are based on the authors’ research and have been peer-reviewed for academic purposes only. Readers are advised to verify all information before practical or commercial use. The journal and its editorial board are not liable for any errors, losses, or consequences arising from its use.

Call For Paper - Volume 11 | Issue 5 | May 2026

IJNRD is a Scholarly Open Access, Peer-Reviewed, Refereed, and UGC CARE Journal Publication with a High Impact Factor of 8.76 (calculated by Google Scholar & Semantic Scholar | AI-Powered Research Tool). It is a Multidisciplinary, Monthly, Low-Cost, and Transparent Peer Review Journal Publication that adheres to the New UGC CARE Transparent Peer-Reviewed Journal Policy and aligns with Scopus Journal Publication standards to ensure the highest level of research quality and credibility.

IJNRD offers comprehensive Journal Publication Services including indexing in all major databases and metadata repositories, Digital Object Identifier (Crossref DOI) assignment for each published article with additional fees, citation generation tools, and full Open Access visibility to enhance global research reach and citation impact.

The INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (IJNRD) aims to advance applied, theoretical, and experimental research across diverse academic and professional fields. The journal promotes global knowledge exchange among researchers, developers, academicians, engineers, and practitioners, serving as a trusted platform for innovative, peer-reviewed journal publication and scientific collaboration.

Indexing Coverage: Google Scholar, SSRN, ResearcherID-Publons, Semantic Scholar (AI-Powered Research Tool), Microsoft Academic, Academia.edu, arXiv.org, ResearchGate, CiteSeerX, ResearcherID (Thomson Reuters), Mendeley, DocStoc, ISSUU, Scribd, and many other recognized academic repositories.

Transparent Peer Review Journal Publication: IJNRD operates a strict double-blind peer review system managed by 3000+ expert reviewers, ensuring ethical, unbiased, and high-quality review for every research paper.

For Indian Authors : Get a transparent peer review report from Scholar9.com for just ₹1000. View Sample Report

For Foreign Authors : A detailed peer review report is available through Scholar9.com for $20 USD. View Sample Report

Transparent Peer Review Journal Publication

⭐ Transparent Peer Review | 🕵️‍♂️ Double-Blind | 👨‍🏫 3000+ Expert Reviewers | 🇮🇳 Report for India Author ₹1000 | 🌐 Report for Foreign Author $20 | 📄 Sample Reports on Scholar9.com | 🌍 High Credibility | ⚖️ Ethical & Unbiased Evaluation

How to submit the paper?

By Our website

Click Here to Submit Paper Online

By Mail

Send your paper to editor@ijnrd.org

Recently, the UGC discontinued the UGC-CARE Journal List and introduced new parameters that allow publication in Transparent Peer-Reviewed (Refereed) Journals. IJNRD is Transparent Peer Review Journal Valid As per New UGC Notification.

You can now publish your research paper in IJNRD.ORG. IJNRD is a Transparent Peer-Reviewed Open Access (Refereed Journal), UGC and UGC CARE Approved, Crossref DOI, Multidisciplinary, Impact Factor calculate by Google Scholar. As an International, open-access, and online journal, Publishing with us ensures wider reach, academic credibility, and enhanced recognition for your work.

For more details, refer to the official notice: UGC Public Notice

⭐ Low Cost ₹1570 | 📚 UGC CARE Approved | 🔍 Peer-Reviewed | 🌐 Open Access | 🔗 Crossref DOI & Global Indexing | 📊 Google Scholar Impact Factor | 🧪 Multidisciplinary

Submit Paper Online  Call for Paper  About IJNRD UGC CARE Approval

Important Dates for Current issue

Paper Submission Open For: May 2026

Current Issue: Volume 11 | Issue 5 | May 2026

Impact Factor: 8.76

Last Date for Paper Submission: Till 31-May-2026

Notification of Review Result: Transparent peer review process - your paper is evaluated by experts, and you receive acceptance or rejection updates via email and SMS.

Publication of Paper: Once all documents are submitted, your paper is published without delay, and you can instantly download your certificate and confirmation letter online.

Frequency: Monthly (12 issue Annually).

Journal Type: IJNRD is an international open-access journal offering Low Cost Journal Publication, transparent Peer Review Journal Publication, Crossref DOI, and multidisciplinary research visibility under UGC CARE Approved Journal Publication.

Subject Category: Research Area

Approval, Licenses and Indexing: More Details

Call For Paper - Volume 11 | Issue 5 | May 2026

IJNRD.org offers low-cost journal publication starting at ₹1570 with UGC CARE Approved, refereed, peer-reviewed, open-access publishing. This multidisciplinary monthly journal, available in both online and print formats, features a strong Google Scholar-based impact factor of 8.76, Transparent Peer Review, CrossRef DOI, global indexing, fast publication, and complete metadata for maximum research visibility and citation impact across multidisciplinary domains.

Volume 11 | Issue 5 | May 2026 | IJNRD Transparent Peer Review Certificate | Submit Paper Online till 31-May-2026

⭐ UGC CARE Approved Refereed Journal | 🔍 Transparent Peer Review | 🌐 Open Access Publishing | 💰 Low-Cost ₹1570 | 🔗 CrossRef DOI & Global Indexing | 📊 Google Scholar Impact Factor 8.76 | 🧪 Multidisciplinary | Online & Print

Submit Paper Online