The Masked Menace : Adrenal Tumor Unveiled Through Precocious Puberty and Virilization

The Masked Menace : Adrenal Tumor Unveiled Through Precocious Puberty and Virilization

Registration ID: IJNRD_226813

Published ID: IJNRD2408384

DOI: http://doi.one/10.1729/Journal.41376

DR. RAKESH ASHOKKUMAR AGARWAL , DR. ATIULLAH M. KHAN , DR. AYESHA KHAN , DR. SUNIL CHOPDE , DR. PRADEEP KUMAR RANABIJULI

ADRENOCORTICAL, VIRILIZATION, HYPERTENSION, HYPERPIGMENTATION

INTRODUCTION Adrenal glands play a crucial role in producing hormones that regulate various bodily functions, including blood pressure, stress response and other body metabolic functions. Adrenal tumors are abnormal growths, located on top of each kidney. Adrenal tumors can be benign (non-cancerous) or malignant (cancerous) and can affect hormone production, leading to a range of symptoms depending on the type of tumor and its function. Adrenocortical carcinoma (ACC) is an aggressive childhood cancer.[1] Adrenocortical tumors are rare in childhood with an incidence of 0.3 to 0.5 cases per 1 million child – years,[2] comprising less than 0.2% of all pediatric neoplasms.[3] They most commonly occur in children younger than 6 years and more frequently in girls. The overall female-to-male ratio is 1.6:1, although it varies widely among age groups. [4] We present a rare case of an Adrenal tumor presented with virilization at our center. CASE HISTORY A 3 Years old female child came with complaints of excessive height and weight gain, associated with hyperpigmentation of skin, new onset hoarseness of voice, development of pubic hair, and hair growth over the body for the past 2 months. The child also exhibited behavioral abnormalities, such as anger outbursts. Birth history and developmental milestones were normal for her age. On examination, the child had hypertrichosis over the face, chest, back, pubic area, and both upper and lower limbs, with hyperpigmentation. There was excessive acne over the face and back. The child had clitoromegaly with a phallic length being 1.8 x 1.5cm. Blood pressure was >95th centile (120/76 mm Hg). Systemic examination was normal and no abdominal mass was palpated. Ultrasound of the abdomen revealed a well-defined bilobed, heterogenous, hypoechoic lesion measuring 5 x 4.2 x 4.5 cm in the right suprarenal region with cystic changes. Routine and hormonal investigations were normal except for elevated serum testosterone and serum DHEA-S levels (Table 1). PET – CT scan revealed FDG - avid Right suprarenal soft tissue mass measuring 5.1 x 4.1 x 3.5 cm with no locoregional adenopathy or distant metastasis. The child is being managed with a multidisciplinary approach and is planned for adrenalectomy, followed by adjuvant treatment based on histopathology. DISCUSSION & CONCLUSION Given its rarity and the complexity of diagnosis, adrenal tumors should be considered in the differential diagnosis of hypertension in young children. Treatment requires a multimodal approach involving a pediatrician, pediatric oncologist, and pediatric surgeon. Clinical, blood investigation and radiological parameters are all necessary to establish the diagnosis. Adrenocortical tumors are treated by total excision, which is generally satisfactory and without complications. The most critical aspect of therapy for adrenocortical tumors is early diagnosis, and total excision remains the treatment of choice.[5][6]

Published Paper   E-Certificate

"The Masked Menace : Adrenal Tumor Unveiled Through Precocious Puberty and Virilization", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.9, Issue 8, page no.d428-d430, August-2024, Available :https://ijnrd.org/papers/IJNRD2408384.pdf

Volume 9 Issue 8, August-2024

Pages : d428-d430

Paper Reg. ID: IJNRD_226813

Published Paper Id: IJNRD2408384

Downloads: 000121116

Research Area: Medical Science

Country: MUMBAI, MAHARASHTRA, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2408384.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2408384

DOI: http://doi.one/10.1729/Journal.41376

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJNRD (IJ Publication) Janvi Wave

This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition

Call For Paper - Volume 10 | Issue 8 | August 2025

IJNRD is Scholarly open access journals, Peer-reviewed, and Refereed Journals, High Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool), Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) with Open-Access Publications.

INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (IJNRD) aims to explore advances in research pertaining to applied, theoretical and experimental Technological studies. The goal is to promote scientific information interchange between researchers, developers, engineers, students, and practitioners working in and around the world. IJNRD will provide an opportunity for practitioners and educators of engineering field to exchange research evidence, models of best practice and innovative ideas.

Indexing In Google Scholar, SSRN, ResearcherID-Publons, Semantic Scholar | AI-Powered Research Tool, Microsoft Academic, Academia.edu, arXiv.org, Research Gate, CiteSeerX, ResearcherID Thomson Reuters, Mendeley : reference manager, DocStoc, ISSUU, Scribd, and many more

How to submit the paper?

Important Dates for Current issue

Paper Submission Open For: August 2025

Current Issue: Volume 10 | Issue 8

Last Date for Paper Submission: Till 31-Aug-2025

Notification of Review Result: Within 1-2 Days after Submitting paper.

Publication of Paper: Within 01-02 Days after Submititng documents.

Frequency: Monthly (12 issue Annually).

Journal Type: International Peer-reviewed, Refereed, and Open Access Journal.

Subject Category: Research Area