FORMULATION AND EVALUATION OF CAFFEINE NASAL DROP FOR THE TREATMENT OF ALZHEIMER DISEASE

FORMULATION AND EVALUATION OF CAFFEINE NASAL DROP FOR THE TREATMENT OF ALZHEIMER DISEASE

Registration ID: IJNRD_227001

Published ID: IJNRD2408351

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Sampat Shankar Bangar , Shital Chavan , Varsha Bapardekar , Kirti Devkate , Janvi Mestri

Nasal drop, Nasal drug delivery system, formulation and in-vitro properties

Caffeine is a widely consumed psychoactive substance known for its stimulating effects on the central nervous system, including enhanced alertness, attention, and cognitive function. While caffeine is traditionally ingested orally, recent research has explored alternative administration routes, such as nasal delivery, to potentially enhance its bioavailability and cognitive effects. This review investigates the feasibility and efficacy of caffeine nasal drops as a novel approach for cognitive enhancement. A comprehensive literature search was conducted to identify relevant studies investigating the pharmacokinetics, pharmacodynamics, and cognitive effects of caffeine nasal drops. The review discusses the nasal mucosa's permeability to caffeine and the potential advantages of nasal delivery in achieving rapid absorption and bypassing first-pass metabolism. For local, systemic, and central nervous system medication delivery, intranasal delivery is the preferred route of drug administration. Nasal drop is an increasingly popular dosage form for nasal drugs because to its benefits, including being affordable, convenient to use and carry, and highly patient compliant delivery. It makes intuitive sense to assume that this review will id in understanding nasal formulation and its in-vitro properties. Overall, preliminary findings suggest that caffeine nasal drops have the potential to offer rapid and effective cognitive enhancement with fewer gastro-intestinal side effects compared to oral administration. However, further research is warranted to optimize dosing regimens, assess long-term safety, and explore the potential applications of caffeine nasal drops in various cognitive tasks and populations. Nasal compositions useful for the delivery of the caffeine alone or with other therapeutic agents.

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"FORMULATION AND EVALUATION OF CAFFEINE NASAL DROP FOR THE TREATMENT OF ALZHEIMER DISEASE", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.9, Issue 8, page no.d454-d466, August-2024, Available :https://ijnrd.org/papers/IJNRD2408351.pdf

Volume 9 Issue 8, August-2024

Pages : d454-d466

Paper Reg. ID: IJNRD_227001

Published Paper Id: IJNRD2408351

Downloads: 000121155

Research Area: Pharmacy

Country: Sindhudurg , Maharashtra, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2408351.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2408351

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJNRD (IJ Publication) Janvi Wave

This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition

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