Paper Title
FORMULATION AND EVALUATION OF CAFFEINE NASAL DROP FOR THE TREATMENT OF ALZHEIMER DISEASE
Article Identifiers
Authors
Sampat Shankar Bangar , Shital Chavan , Varsha Bapardekar , Kirti Devkate , Janvi Mestri
Keywords
Nasal drop, Nasal drug delivery system, formulation and in-vitro properties
Abstract
Caffeine is a widely consumed psychoactive substance known for its stimulating effects on the central nervous system, including enhanced alertness, attention, and cognitive function. While caffeine is traditionally ingested orally, recent research has explored alternative administration routes, such as nasal delivery, to potentially enhance its bioavailability and cognitive effects. This review investigates the feasibility and efficacy of caffeine nasal drops as a novel approach for cognitive enhancement. A comprehensive literature search was conducted to identify relevant studies investigating the pharmacokinetics, pharmacodynamics, and cognitive effects of caffeine nasal drops. The review discusses the nasal mucosa's permeability to caffeine and the potential advantages of nasal delivery in achieving rapid absorption and bypassing first-pass metabolism. For local, systemic, and central nervous system medication delivery, intranasal delivery is the preferred route of drug administration. Nasal drop is an increasingly popular dosage form for nasal drugs because to its benefits, including being affordable, convenient to use and carry, and highly patient compliant delivery. It makes intuitive sense to assume that this review will id in understanding nasal formulation and its in-vitro properties. Overall, preliminary findings suggest that caffeine nasal drops have the potential to offer rapid and effective cognitive enhancement with fewer gastro-intestinal side effects compared to oral administration. However, further research is warranted to optimize dosing regimens, assess long-term safety, and explore the potential applications of caffeine nasal drops in various cognitive tasks and populations. Nasal compositions useful for the delivery of the caffeine alone or with other therapeutic agents.
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How To Cite (APA)
Sampat Shankar Bangar , Shital Chavan, Varsha Bapardekar, Kirti Devkate, & Janvi Mestri (August-2024). FORMULATION AND EVALUATION OF CAFFEINE NASAL DROP FOR THE TREATMENT OF ALZHEIMER DISEASE. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(8), d454-d466. https://ijnrd.org/papers/IJNRD2408351.pdf
Issue
Volume 9 Issue 8, August-2024
Pages : d454-d466
Other Publication Details
Paper Reg. ID: IJNRD_227001
Published Paper Id: IJNRD2408351
Downloads: 000122000
Research Area: Pharmacy
Country: Sindhudurg , Maharashtra, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2408351.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2408351
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Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)
ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016
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This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition
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IJNRD is a Scholarly Open Access, Peer-reviewed, and Refereed Journal with a High Impact Factor of 8.76 (calculated by Google Scholar & Semantic Scholar | AI-Powered Research Tool). It is a Multidisciplinary, Monthly, Low-Cost Journal that follows UGC CARE 2025 Peer-Reviewed Journal Policy norms, Scopus journal standards, and Transparent Peer Review practices to ensure quality and credibility. IJNRD provides indexing in all major databases & metadata repositories, a citation generator, and Digital Object Identifier (DOI) for every published article with full open-access visibility.
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