“PHARMACOLOGICAL EVALUATION OF ANTI-CONVULSANT ACTIVITY OF LIPOSOMES CONTAINING VITEXNUGEUNDO”

Registration ID: IJNRD_227031

Published ID: IJNRD2408340

DOI: Click Here to Get

Ms. Ambika D.Nagarbhdiya , Dr. Ranajit D.Tijare , Ms. Varsha M. Kharat

Antiepileptic,Vitex-negundo, Electroconvulsiometer, Maximum Electroshock (MES), Verbenaceae, Cynogenetic glycosides.

The vitexnugeundo or nirgudi is a native plant of India different part of which are used in the treatment of various diseases such as: analgesic, hepatoprotective, anxiolytic, anti-inflammatory, asthma, hormonal disorder etc. The purpose of this study was to prepare & evaluate extract &also liposome formulation consisting of methanol extract of leaves of vitexnegundo for the treatment of convulsion induced by PTZmodel & MES induced seizure using animals. The present study was novel as it consisted of utilizing the extract of same plant prepared by using various solvents. The extract was prepared using the combined solvents, consisting of ethanol, methanol, chloroform and water in the ratio 1:1. The prepared mixture of the solvent was used for the extraction of phytoconstituents, which revealed that, the prepared combined solvent showed the significant increment in the extractive value. Further same extract was screen for anti-convulsant activity using PTZ model, and results revealed that the significant anticonvulsant activity. Whereas the other extracts, which were prepared using solvents like ethanol, methanol, chloroform and water showed less extractive value and less anti-convulsant activity as compared to combined solvent extract. This novelty proved significantly in the present study. The significant activity of the plant was may be due to the presence of the few of the chemical constituents like, Flavonoids, Saponins and the cynogenetic glycosides also. The phytochemical investigation showed the presence of these chemicals in the plant extracts, which act as a strong base for the significant results, proved by the Tukey Kramer method.

Published Paper   E-Certificate

Ms. Ambika D.Nagarbhdiya, Dr. Ranajit D.Tijare, & Ms. Varsha M. Kharat (August-2024). “PHARMACOLOGICAL EVALUATION OF ANTI-CONVULSANT ACTIVITY OF LIPOSOMES CONTAINING VITEXNUGEUNDO”. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(8), d345-d354. https://ijnrd.org/papers/IJNRD2408340.pdf

Volume 9 Issue 8, August-2024

Pages : d345-d354

Paper Reg. ID: IJNRD_227031

Published Paper Id: IJNRD2408340

Downloads: 000121979

Research Area: Pharmacy

Country: Pusad (445204), Maharashtra, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2408340.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2408340

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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