Paper Title
FORMULATION AND EVALUATION OF PROPRANOLOL HYDROCHLORIDE TRANSDERMAL PATCHES
Article Identifiers
Authors
Kedar Tukaram K. , Mali. M.R. , Farzana Kazi , Kishor Patil , Pranay satam
Keywords
Patch, propranolol hydrochloride ,polymer Trasdermal
Abstract
Since propranolol hydrochloride has a high first-pass metabolism and a low oral bioavailability, various matrix-type transdermal patches containing the drug were developed with the goal of examining the impact of the polymer on transdermal release. The polymers chosen to maintain the drug's release. HPMC, et cetera, were the polymers chosen to maintain the drug's release. Methanol and polymer were used to create the patches. For patients who are unable to take their medication orally, this is one of the greatest pharmaceutical dose forms available. When transdermal patches are applied, TDDS has established itself as a crucial component of innovative drug delivery systems since the medication's distribution through the dermis has a systemic effect. An expensive substitute for traditional formulation is TDDS. Using solvent evaporation techniques, a matrix-type transdermal patch containing propranolol hydrochloride and a mixture of HPMC was to be developed. In the methanol solvent system, methanol served as a penetration booster. Physical evaluations were conducted to assess the drug content, moisture content, thickness, weight change, and folding endurance of transdermal films. Every compound created showed a high degree of physical stability. In terms of their physical parameters and drug content, all of the films were determined to be stable between 37°C and 45°C.
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How To Cite (APA)
Kedar Tukaram K., Mali. M.R., Farzana Kazi , Kishor Patil, & Pranay satam (August-2024). FORMULATION AND EVALUATION OF PROPRANOLOL HYDROCHLORIDE TRANSDERMAL PATCHES. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(8), d212-d224. https://ijnrd.org/papers/IJNRD2408327.pdf
Issue
Volume 9 Issue 8, August-2024
Pages : d212-d224
Other Publication Details
Paper Reg. ID: IJNRD_226993
Published Paper Id: IJNRD2408327
Downloads: 000122000
Research Area: Pharmacy
Country: Sindhudurg, Maharashtra, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2408327.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2408327
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This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition
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