Evaluation of Anti-hyperglycemic activity of Kakamachi (Solanum nigrum Linn.) leaves on Wistar albino rats.

Evaluation of Anti-hyperglycemic activity of Kakamachi (Solanum nigrum Linn.) leaves on Wistar albino rats.

Registration ID: IJNRD_226886

Published ID: IJNRD2408300

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Dr. Mahalaxmi , Dr. Shashidhar S. Sarawad , Dr. Nandan S. Hodlur

Anti-hyperglycemic, Kakamachi (Solanum Nigrum.Linn)

INTRODUCTION: Diabetes mellitus is a clinical syndrome characterized by Hyperglycaemia due to absolute or relative deficiency of insulin. Diabetes and its complication pose a major threat to future public health resources throughout the world. According to National Urban Diabetes Survey (NUDS), the prevalence of diabetes is high in urban India; due to change in lifestyle leading to reduced physical activity and increased obesity. Based on a compilation of studies from different parts of the world, the World Health Organization (WHO) has projected that the maximum increase in diabetes would occur in India. Now India has been declared as a “capital of diabetes” because it is one of the five countries which have highest sufferers of Diabetes Mellitus. In Ayurvedic classics it is explained that mehaghna is one of the karma of drug Kakamachi. The present research work was conducted to analyse the Anti-hyperglycemic action of the drug Kakamachi (leaves). METHDOLOGY: Kakamachi leaves were collected from natural habitat. Macroscopic and microscopic study of the leaf was carried out. Pharmacognostic and Phytochemical tests are performed as per the standards of Ayurvedic Pharmacopoeia. Anti-hyperglycemic activity of Kakamachi leaves evaluated in Wistar albino rats using Fructose induced diabetes model. Statistically results were analyzed by using Anova test followed by dunnet’s test. RESULTS: Anti-hyperglycemic activity of Kakamachi leaves showed significant reduction in the hyperglycemia (p<0.001) when compared to Control group. CONCLUSION: Aqueous extract of Kakamachi leaves at the dosage of 200mgkg significantly reduced the Fructose induced hyperglycemia (p<0.001)in comparison with Control group.

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"Evaluation of Anti-hyperglycemic activity of Kakamachi (Solanum nigrum Linn.) leaves on Wistar albino rats.", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.9, Issue 8, page no.c894-c899, August-2024, Available :https://ijnrd.org/papers/IJNRD2408300.pdf

Volume 9 Issue 8, August-2024

Pages : c894-c899

Paper Reg. ID: IJNRD_226886

Published Paper Id: IJNRD2408300

Downloads: 000121186

Research Area: Medical Science

Country: Bagalkot, Karnataka, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2408300.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2408300

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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