Paper Title
Development of In-vitro characterization of transfersomes of gel for the transdermal delivery of testosterone
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Authors
Pankaj Bansal
Keywords
Abstract
This study focuses on developing a testosterone-loaded transferosome gel to enhance transdermal delivery. Organoleptic evaluation confirmed testosterone as a white, odorless powder. Melting point and partition coefficient were determined at 154.33°C and 3.436, respectively. UV analysis revealed an absorption maximum at 241 nm with high linearity (R² = 0.999) within a concentration range of 1-10 µg/ml. Solubility studies indicated maximum solubility in chloroform and minimal solubility in water. The transferosome formulation TT7 achieved a drug entrapment of 83.29% with a vesicle size of 286.2 nm and a zeta potential of -26.2 mV. Incorporating TT7 into a gel with varying carbopol concentrations resulted in pH values suitable for skin application (6.167 to 6.233). In vitro drug release studies demonstrated that the transferosome gel released 95.51% of testosterone within 24 hours, following the Higuchi model (R² = 0.932). These findings support the potential of the transferosome gel for effective testosterone delivery through the skin.
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How To Cite (APA)
Pankaj Bansal (August-2024). Development of In-vitro characterization of transfersomes of gel for the transdermal delivery of testosterone. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(8), c645-c650. https://ijnrd.org/papers/IJNRD2408271.pdf
Issue
Volume 9 Issue 8, August-2024
Pages : c645-c650
Other Publication Details
Paper Reg. ID: IJNRD_226768
Published Paper Id: IJNRD2408271
Downloads: 000121986
Research Area: Pharmacy
Country: Sangrur , Punjab, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2408271.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2408271
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Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)
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