Study of analgesic and anti-inflammatory potential of hydro-alcoholic extract of Curcuma angustifolia leaf

Registration ID: IJNRD_226590

Published ID: IJNRD2408221

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Bhavna Kanjolia , Amit Jain , Sandeep Kumar Jain

Anti-nociceptive, Anti-inflammatory, Curcuma angustifolia, Edema, Extract,

The objective of the study was to assess the anti-nociceptive and anti-inflammatory potential of the aqueous extract of Curcuma angustifolia leaves. The defatting of leaf powder was achieved by extraction with n-hexane and the de-fatted leaf powder was then extracted with distilled water for collection of maximum amount of water soluble extractives. The extracts were sticky and the aqueous extract was dark brown in color with 14.6% yield. The preliminary phytochemical analysis suggest the presence of saponin glycosides, cardiac glycosides, phenolics, terpenoids, sterols, and flavonoids in the leaves. The total phenolic content of the aqueous extract of Curcuma angustifolia was 76.28 ± 0.45 GAE mg/g. The anti-inflammatory activity was assessed using carrageenan induced rat paw edema method while the analgesic action was determined using tail flick method. Ibuprofen at dose of 10 mg/Kg inhibited 80.36% edema after 6h of administration while the CAE 200 and CAE 400 were able to inhibit 46.33% and 51.02% edema formation respectively. The duration of response time in Ibuprofen and Curcuma angustifolia was significantly higher as compared to the saline treated animals. The reaction time for CAE 200 and CAE 400 was 6.086 ± 0.089 sec and 6.602 ± 0.126 sec respectively at 60 min post administration while it was 3.038 ± 0.036 sec and 7.946 ± 0.301 sec for vehicle treated group and Ibuprofen respectively at the same time duration.

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Bhavna Kanjolia, Amit Jain, & Sandeep Kumar Jain (August-2024). Study of analgesic and anti-inflammatory potential of hydro-alcoholic extract of Curcuma angustifolia leaf. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(8), c189-c198. https://ijnrd.org/papers/IJNRD2408221.pdf

Volume 9 Issue 8, August-2024

Pages : c189-c198

Paper Reg. ID: IJNRD_226590

Published Paper Id: IJNRD2408221

Downloads: 000121998

Research Area: Biological Science

Country: Gwalior, Madhya Pradesh, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2408221.pdf

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Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

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