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Paper Title

Prevalence and Determinants of Herpes Simplex Virus type 2: A Rural-Urban Comparison among HIV-Infected and Uninfected Pregnant Women in Cross River State, Nigeria

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Registration ID: IJNRD_226465

Published ID: IJNRD2408205

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Keywords

Herpes simplex virus, Human immunodeficiency virus, Seroprevalence, Enzyme-linked immunosorbent test.

Abstract

ABSTRACT: Preventing neonatal herpes is a crucial step in combating herpes simplex virus infection. Knowing the HSV status of the mother is advantageous. Furthermore, HSV infection serves as a biological cofactor for HIV infection, a disease that has reached pandemic levels. Conducting screenings on pregnant women for HSV infection would enable the identification of women who are at risk and facilitate measures to prevent neonatal infection. GOAL: To assess and contrast the occurrence rate of HSV type 2 in pregnant women who are infected with HIV and those who are not infected with HIV. PROCEDURE: Serum samples from a total of 300 pregnant women, with 150 being HIV infected and 150 being HIV uninfected, were examined for the presence of HSV-2 IgG antibodies. Female participants who were less than 36 weeks pregnant got optional counselling, followed by testing for their HIV and HSV-2 status using a commercially available kit called CALBIOTECH HSV-2 IgG ELISA. The study aimed to establish the seroprevalence of HSV type 2, as well as the prevalence of HSV type 2 and HIV co-infection. A seroprevalence comparison was conducted between customers infected with HIV and clients not infected with HIV to determine the prevalence of HSV type 2. A comparison was also conducted between rural and urban areas regarding the incidence of HSV type 2. The data collected were analysed using the Statistical Package for the Social Sciences (SPSS). The researchers employed multivariate logistic regression to determine the independent factors that predict HSV type 2 infections. The prevalence of HSV-2 among pregnant women infected with HIV was 83.3%, whereas it was 80.7% among pregnant women not infected with HIV. Among rural inhabitants, the prevalence was 74.4%, while among urban dwellers, it was 87.4%. The factors that were shown to be linked with HSV-2 seropositivity were the level of knowledge about HSV-2 (X2=5.426; p=0.020), the location of the responder (X2=13.102; p=0.001), and the age of the spouse (FET;9.933, p=0.047). The age of the spouse was found to be a significant predictor of HVS type 2 seropositivity, as determined by a multivariate binary logistic regression analysis. CONCLUSION: The incidence of HSV-2 is considerably elevated among pregnant women in Cross River state, Nigeria. It is necessary to formulate methods with the objective of decreasing HSV-2 infection rates among pregnant women.

How To Cite (APA)

Sylvester E Abeshi, Chiegina O Godwin, Ezukwa O Ezukwa, & Edet E Ekpo (August-2024). Prevalence and Determinants of Herpes Simplex Virus type 2: A Rural-Urban Comparison among HIV-Infected and Uninfected Pregnant Women in Cross River State, Nigeria. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(8), c36-c47. https://ijnrd.org/papers/IJNRD2408205.pdf

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Other Publication Details

Paper Reg. ID: IJNRD_226465

Published Paper Id: IJNRD2408205

Research Area: Medical Science

Author Type: Foreign Author

Country: Calabar, Cross River State, Nigeria

Published Paper PDF: https://ijnrd.org/papers/IJNRD2408205.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2408205

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