DEVELOPMENT AND IN VITRO CHARACTERIZATION OF LIPOSHERE GEL FOR ANTIFUNGAL DRUG ECONAZOLE

Registration ID: IJNRD_226428

Published ID: IJNRD2408180

DOI: Click Here to Get

Ankit Bansal

Multiple-unit drug delivery systems provide advantages over single-unit systems by ensuring a uniform distribution in the gastrointestinal tract, leading to consistent drug absorption. However, these systems may face challenges such as polymer breakdown and the presence of organic solvent residues, which could pose acceptability and toxicity concerns. To address these issues, a novel fat-based encapsulation technology known as lipospheres has been proposed. Lipospheres are solid lipid particles with a size range of 0.01 to 100 μm, containing a hydrophobic lipid core with the active drug, stabilized by an external layer of phospholipid molecules. Liposphere systems offer improved stability, freeze-dry properties, controlled particle size, high drug load, precise drug release, and low carrier toxicity compared to other particulate delivery systems. They shield drug candidates from hydrolysis, ensuring shelf life, good bioavailability, sustained plasma levels, and controlled delivery of various medications such as anti-inflammatory drugs, local anesthetics, antibiotics, and anticancer medicines. Lipospheres can also enhance the delivery of lipid-entrapped vaccines with an adjuvant effect. The aim of this project was to develop an econazole-loaded liposphere gel to improve the drug's loading and release. The preformulation study revealed the melting point of econazole nitrate to be in the range of 161.34°C±0.57-164.67°C±1.15, with an absorption maxima at 271nm. The drug exhibited solubility in methanol and ethanol but was sparingly soluble in chloroform and phosphate buffer pH 6.8. Lipospheres were prepared using a melt dispersion method, with screening involving different lipids, lipid amounts, and stirring speeds. Formulations with stearic acid appeared spherical and uniform, while those with other lipids were non-uniform. The percentage yield of prepared liposphere formulations ranged from 50.835±0.979 to 97.099±0.320, with drug entrapment ranging from 23.141±0.084% to 89.556±0.568%. The selected formulation (EL8) was incorporated into a gel carrier with varying concentrations of carbopol 934 (1%, 1.5%, and 2% w/w). The percentage drug content in the gel formulations ranged from 89.714±0.451% to 99.089±1.193%, indicating uniform distribution of lipospheres in the gel matrix. Viscosity of the gel formulations ranged from 699.000±1.00cp to 6314.667±3.512cp. Econazole nitrate release profiles from the liposphere gel formulations showed nearly 100% release for EL8G2, roughly 98% for EL8G3 after 24 hours, and a regression coefficient value of 0.931 for the Higuchi model, indicating that the release follows this model.

Published Paper   E-Certificate

Ankit Bansal (August-2024). DEVELOPMENT AND IN VITRO CHARACTERIZATION OF LIPOSHERE GEL FOR ANTIFUNGAL DRUG ECONAZOLE. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(8), b839-b844. https://ijnrd.org/papers/IJNRD2408180.pdf

Volume 9 Issue 8, August-2024

Pages : b839-b844

Paper Reg. ID: IJNRD_226428

Published Paper Id: IJNRD2408180

Downloads: 000121985

Research Area: Pharmacy

Country: Cheema Mandi Distt : Sangrur, Punjab, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2408180.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2408180

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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