SIMULTANEOUS ESTIMATION OF PIRACETAM AND CARBAMAZEPINE IN BULK AND PHARMACEUTICAL DOSAGE FORM BY USING RP-HPLC

SIMULTANEOUS ESTIMATION OF PIRACETAM AND CARBAMAZEPINE IN BULK AND PHARMACEUTICAL DOSAGE FORM BY USING RP-HPLC

Registration ID: IJNRD_226272

Published ID: IJNRD2408117

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Miss Shubhnagi Sanjay Doiphode , Mr.Sandip Adhude , Miss. Prajakta Golhar

RP-HPLC, chromatographic saperation, spectroscopy.

RP-HPLC method has shown adequate simultaneous separation for a Piracetam & Carbamazepine . For the method development, several preliminary trial runs were taken on the pre-validated RP-HPLC system by varying the concentration of mobile and different solvent containing various ratios of acetonitrile, methanol, water and phosphate buffer pH 7.4 were tried for separation and resolution of peaks of both drugs to get the optimized parameters. Finally, chromatographic separation was carried out with Inertsil C18 (4.6 x 250mm, 5μm). The mobile phase used for isocratic elution was prepared by mixing phosphate buffer pH 7.4: methanol (50:50 v/v). Before use, the mobile phase was filtered through 0.45 μm membrane filter and degassed by ultrasonication. The flow rate was 1.0 mL/min, column temperature ambient, the injection volume was 20 μl, and detection was performed at 260 nm using a UV detector. The retention time was obtained to be 3.51±0.15 min for piracetam and 4.82 ±0.21 min

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"SIMULTANEOUS ESTIMATION OF PIRACETAM AND CARBAMAZEPINE IN BULK AND PHARMACEUTICAL DOSAGE FORM BY USING RP-HPLC ", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.9, Issue 8, page no.b255-b277, August-2024, Available :https://ijnrd.org/papers/IJNRD2408117.pdf

Volume 9 Issue 8, August-2024

Pages : b255-b277

Paper Reg. ID: IJNRD_226272

Published Paper Id: IJNRD2408117

Downloads: 000121130

Research Area: Engineering

Country: -, -, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2408117.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2408117

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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