Paper Title
DEVELOPMENT & VALIDATION OF STABILITY INDICATING HPLC METHOD FOR THE DETERMINATION OF CHROMATOGRAPHIC PURITY OF FLUVASTATIN SODIUM
Article Identifiers
Authors
Nirmal Kashyap , Aditya Mathur , Shivangi pandit
Keywords
Fluvastatin sodium, HPLC, Hypertension ischemic coronary artery disease, Mobile phase, linearity
Abstract
A precise and simple HPLC technique was developed and validated for the measurement of Fluvastatin sodium. The statin family of drugs, which include fluvastatin sodium, inhibits the reductase enzyme that breaks down 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA). The drug is used to treat ischemic coronary artery disease and hypertension. Additionally, it is used to treat dyslipidemia and lower "bad cholesterol" levels. The method was used on a C18 column (250 4.6mm 1.d; 5) in isocratic mode with acetonitrile and water as the mobile phases in a 75:25 v/v ratio. The flow rate is 0.6 millilitres per minute, and the wavelength is 242 nm. With a correlation coefficient of 0.9998, the linearity between 10 and 60 microgram per ml was identified. Because the suggested method is straightforward, rapid, accurate, precise, and repeatable, it can be utilised for routine quality control analysis of fluvastatin in both pure and tablet dosage forms. The medicine has a retention time of 3.643.
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How To Cite (APA)
Nirmal Kashyap, Aditya Mathur , & Shivangi pandit (August-2024). DEVELOPMENT & VALIDATION OF STABILITY INDICATING HPLC METHOD FOR THE DETERMINATION OF CHROMATOGRAPHIC PURITY OF FLUVASTATIN SODIUM. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(8), b210-b222. https://ijnrd.org/papers/IJNRD2408115.pdf
Issue
Volume 9 Issue 8, August-2024
Pages : b210-b222
Other Publication Details
Paper Reg. ID: IJNRD_226253
Published Paper Id: IJNRD2408115
Downloads: 000121978
Research Area: Pharmacy
Country: Motihari, Bihar, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2408115.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2408115
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