DEVELOPMENT & VALIDATION OF STABILITY INDICATING HPLC METHOD FOR THE DETERMINATION OF CHROMATOGRAPHIC PURITY OF FLUVASTATIN SODIUM

DEVELOPMENT & VALIDATION OF STABILITY INDICATING HPLC METHOD FOR THE DETERMINATION OF CHROMATOGRAPHIC PURITY OF FLUVASTATIN SODIUM

Registration ID: IJNRD_226253

Published ID: IJNRD2408115

DOI: Click Here to Get

Nirmal Kashyap , Aditya Mathur , Shivangi pandit

Fluvastatin sodium, HPLC, Hypertension ischemic coronary artery disease, Mobile phase, linearity

A precise and simple HPLC technique was developed and validated for the measurement of Fluvastatin sodium. The statin family of drugs, which include fluvastatin sodium, inhibits the reductase enzyme that breaks down 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA). The drug is used to treat ischemic coronary artery disease and hypertension. Additionally, it is used to treat dyslipidemia and lower "bad cholesterol" levels. The method was used on a C18 column (250 4.6mm 1.d; 5) in isocratic mode with acetonitrile and water as the mobile phases in a 75:25 v/v ratio. The flow rate is 0.6 millilitres per minute, and the wavelength is 242 nm. With a correlation coefficient of 0.9998, the linearity between 10 and 60 microgram per ml was identified. Because the suggested method is straightforward, rapid, accurate, precise, and repeatable, it can be utilised for routine quality control analysis of fluvastatin in both pure and tablet dosage forms. The medicine has a retention time of 3.643.

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"DEVELOPMENT & VALIDATION OF STABILITY INDICATING HPLC METHOD FOR THE DETERMINATION OF CHROMATOGRAPHIC PURITY OF FLUVASTATIN SODIUM", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.9, Issue 8, page no.b210-b222, August-2024, Available :https://ijnrd.org/papers/IJNRD2408115.pdf

Volume 9 Issue 8, August-2024

Pages : b210-b222

Paper Reg. ID: IJNRD_226253

Published Paper Id: IJNRD2408115

Downloads: 000121121

Research Area: Pharmacy

Country: Motihari, Bihar, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2408115.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2408115

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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