"REVOLUTIONIZING WOUND CARE: DEVELOPMENT AND ASSESSMENT OF A CURCUMIN-BASED GEL FOR ENHANCED HEALING"

Registration ID: IJNRD_226318

Published ID: IJNRD2408080

DOI: Click Here to Get

Mr. Ajay R. Wagh , Prof. Pravin Parekh , Prof. Kalpesh Wagh , Mr. Sagar R. Koli

Curcumin, Gel, Wound Healing, DSC, FT-IR etc.

Curcumin, a compound from Curcuma longa, is renowned for its therapeutic properties, including antioxidant, anti-inflammatory, anticancer, antibacterial, wound healing, antiviral, hepatoprotective, and neuroprotective effects. Despite its high-dose safety, its poor water solubility hampers its efficacy. This study aimed to enhance curcumin's solubility using a gel formulation with Gelucire 44/14. Both curcumin and Gelucire 44/14 were confirmed via physicochemical and spectral analyses. Various proportions were tested, with a 1:3 ratio of curcumin to Gelucire 44/14 achieving the highest water solubility. Stability studies indicated that at 40°C, Gelucire 44/14 melted, impacting stability. FT-IR analysis suggested hydrogen bond interactions, while DSC and TGA confirmed thermal stability and interaction-driven solubilization. The 1:3 ratio significantly enhanced curcumin solubility, and gel formulations demonstrated faster and higher curcumin release, peaking at 60-90 minutes, compared to plain curcumin. In rat models, the gel improved wound healing efficacy over plain curcumin. However, stability issues arose at 40°C due to Gelucire melting, necessitating further formulation adjustments for better stability. These findings suggest that Gelucire 44/14 is promising excipients for enhancing curcumin solubility and therapeutic efficacy, though temperature stability remains a challenge.

Published Paper   E-Certificate

Mr. Ajay R. Wagh, Prof. Pravin Parekh, Prof. Kalpesh Wagh, & Mr. Sagar R. Koli (August-2024). "REVOLUTIONIZING WOUND CARE: DEVELOPMENT AND ASSESSMENT OF A CURCUMIN-BASED GEL FOR ENHANCED HEALING". INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(8), a876-a889. https://ijnrd.org/papers/IJNRD2408080.pdf

Volume 9 Issue 8, August-2024

Pages : a876-a889

Paper Reg. ID: IJNRD_226318

Published Paper Id: IJNRD2408080

Downloads: 000121981

Research Area: Pharmacy

Country: Dhule, Maharashtra, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2408080.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2408080

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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