Paper Title
Review on Mycobacterium species multidrug resistance
Article Identifiers
: Keywords
Multi drug resistance M.tuberculosis M.leprae Mechanism of drug resistance
Abstract
One major barrier to efficient treatment and disease control is multi-drug resistance (MDR) in Mycobacterium leprae (ML) and Mycobacterium tuberculosis (MTB). An overview of the MDR mechanisms in these infections and the medications used to combat their resistance is give in this abstract. mutations in the genes that code for the targets of drugs or the activation enzymes of drugs or metabolism are frequently the cause of MDR in MTB. Important first-line medications like rifampicin and isoniazid target essential cellular functions including RNA transcription and cell wall formation. Resistance mechanisms, such as changes in genes like rpoB and katG, impair the effectiveness of drugs. Gene alterations such as gyrA and rrs impair second-line medications, such as fluoroquinolones and injectable treatments, increasing treatment obstacles and resulting in extensively drug-resistant tuberculosis (XDR-TB). Similar to this, drug target genes, such as folP1 for dapsone and rpoB for rifampicin, as well as efflux pumps and metabolic pathways, are mutated in M. Leprae resistance mechanisms. Many different types of medications with different mechanisms of action are used to fight MDR in MTB and M.Leprae. Novel treatments targeting alternate routes are being developed in addition to traditional antibiotics. To reduce resistance and improve treatment effectiveness, combination medicines that are customized to each patient's unique resistance profile are crucial. Molecular assays and whole-genome sequencing are two examples of diagnostic breakthroughs that enable prompt therapeutic interventions by facilitating the quick identification of drug resistance mutations.
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How To Cite (APA)
Dr. K. Purna Nagasree, N. Uma amruta, S. Aishwarya amruta, R. Meghana, & Jagadeesh Panda (August-2024). Review on Mycobacterium species multidrug resistance. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(8), a540-a547. https://ijnrd.org/papers/IJNRD2408049.pdf
Issue
Volume 9 Issue 8, August-2024
Pages : a540-a547
Other Publication Details
Paper Reg. ID: IJNRD_226099
Published Paper Id: IJNRD2408049
Downloads: 000122253
Research Area: Pharmacy
Author Type: Indian Author
Country: visakhapatnam, Andhra pradesh, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2408049.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2408049
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