Review on Mycobacterium species multidrug resistance

Review on Mycobacterium species multidrug resistance

Registration ID: IJNRD_226099

Published ID: IJNRD2408049

DOI: Click Here to Get

Dr. K. Purna Nagasree , N. Uma amruta , S. Aishwarya amruta , R. Meghana , Jagadeesh Panda

Multi drug resistance M.tuberculosis M.leprae Mechanism of drug resistance

One major barrier to efficient treatment and disease control is multi-drug resistance (MDR) in Mycobacterium leprae (ML) and Mycobacterium tuberculosis (MTB). An overview of the MDR mechanisms in these infections and the medications used to combat their resistance is give in this abstract. mutations in the genes that code for the targets of drugs or the activation enzymes of drugs or metabolism are frequently the cause of MDR in MTB. Important first-line medications like rifampicin and isoniazid target essential cellular functions including RNA transcription and cell wall formation. Resistance mechanisms, such as changes in genes like rpoB and katG, impair the effectiveness of drugs. Gene alterations such as gyrA and rrs impair second-line medications, such as fluoroquinolones and injectable treatments, increasing treatment obstacles and resulting in extensively drug-resistant tuberculosis (XDR-TB). Similar to this, drug target genes, such as folP1 for dapsone and rpoB for rifampicin, as well as efflux pumps and metabolic pathways, are mutated in M. Leprae resistance mechanisms. Many different types of medications with different mechanisms of action are used to fight MDR in MTB and M.Leprae. Novel treatments targeting alternate routes are being developed in addition to traditional antibiotics. To reduce resistance and improve treatment effectiveness, combination medicines that are customized to each patient's unique resistance profile are crucial. Molecular assays and whole-genome sequencing are two examples of diagnostic breakthroughs that enable prompt therapeutic interventions by facilitating the quick identification of drug resistance mutations.

Published Paper   E-Certificate

"Review on Mycobacterium species multidrug resistance", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.9, Issue 8, page no.a540-a547, August-2024, Available :https://ijnrd.org/papers/IJNRD2408049.pdf

Volume 9 Issue 8, August-2024

Pages : a540-a547

Paper Reg. ID: IJNRD_226099

Published Paper Id: IJNRD2408049

Downloads: 000121144

Research Area: Pharmacy

Country: visakhapatnam, Andhra pradesh, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2408049.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2408049

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJNRD (IJ Publication) Janvi Wave

This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition

Call For Paper - Volume 10 | Issue 8 | August 2025

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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (IJNRD) aims to explore advances in research pertaining to applied, theoretical and experimental Technological studies. The goal is to promote scientific information interchange between researchers, developers, engineers, students, and practitioners working in and around the world. IJNRD will provide an opportunity for practitioners and educators of engineering field to exchange research evidence, models of best practice and innovative ideas.

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