Paper Title
Synthesis, and Biological Assessment of 5-arylidene derivatives of 2-((2-fluoro-3-(morpholine-4-carbonyl) phenyl) imino) thiozolidin-4-one with Promising Antimicrobial and Antioxidant Properties
Article Identifiers
Authors
Parag S. Kurle , Jayshree Parikh , Shrikant S. Gawande , Vijay H. Petha , Bharti P. Deshmukh
Keywords
Thiozolidin-4-one, Morpholine, Antioxidant, Antimicrobial
Abstract
This study presents the synthesis, structural analysis, and biological evaluation of twelve new aldehyde derivatives combining Morpholine and Thiazolidinone scaffolds. The compounds, purified through column chromatography or recrystallization and tested for their antimicrobial and antioxidant properties. Specifically, compounds 7c, 7d, 7f, and 7k demonstrated significant antibacterial activity against gram-positive and gram-negative bacteria, with MICs comparable to reference standard. Chloro-substituted benzaldehyde derivatives exhibited enhanced activity against certain bacterial strains. Several compounds also outperformed the reference drug Nystatin in antifungal activity against Aspergillus Niger, and compounds 7e, 7f, 7k, and 7l showed similar effectiveness against Candida albicans. Antioxidant assessments revealed substantial DPPH inhibition, particularly in compounds 7f, 7h, 7i, 7j, and 7l, comparable with standard drug efficacy at higher doses. These findings suggest the potential of these compounds in treating oxidative stress and microbial infections, warranting further investigation into their mechanisms and therapeutic applications, along with possible chemical structure optimization for enhanced potency.
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How To Cite (APA)
Parag S. Kurle, Jayshree Parikh, Shrikant S. Gawande, Vijay H. Petha, & Bharti P. Deshmukh (August-2024). Synthesis, and Biological Assessment of 5-arylidene derivatives of 2-((2-fluoro-3-(morpholine-4-carbonyl) phenyl) imino) thiozolidin-4-one with Promising Antimicrobial and Antioxidant Properties. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(8), a308-a316. https://ijnrd.org/papers/IJNRD2408029.pdf
Issue
Volume 9 Issue 8, August-2024
Pages : a308-a316
Other Publication Details
Paper Reg. ID: IJNRD_226195
Published Paper Id: IJNRD2408029
Downloads: 000121980
Research Area: Chemistry
Country: Navi Mumbai, thane , Maharashtra, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2408029.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2408029
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Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)
ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016
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This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition
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IJNRD is a Scholarly Open Access, Peer-reviewed, and Refereed Journal with a High Impact Factor of 8.76 (calculated by Google Scholar & Semantic Scholar | AI-Powered Research Tool). It is a Multidisciplinary, Monthly, Low-Cost Journal that follows UGC CARE 2025 Peer-Reviewed Journal Policy norms, Scopus journal standards, and Transparent Peer Review practices to ensure quality and credibility. IJNRD provides indexing in all major databases & metadata repositories, a citation generator, and Digital Object Identifier (DOI) for every published article with full open-access visibility.
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