Paper Title
THE EFFECTIVENESS OF 3HP ON TREATMENT OF LATENT TB INFECTION IN ADOLESCENT AND ADULT PLHIV IN TANZANIA:
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Registration ID: IJNRD_226175
Published ID: IJNRD2408009
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Abstract
Background: is the commonest opportunistic infection in PLHIV, People who harbor LTBI are the important reservoirs of active TB disease. LTBI treatment is intended to prevent progression of LTBI from dormant state to active TB disease there by reducing the burden of morbidities and mortalities in PLHIV. WHO recommends the use of shorter regimens including 3HP in treating LTBI to people at risk of developing active TB disease. This study aimed at reviewing the effectiveness of 3HP on treatment of LTBI in adolescent and adult PLHIV Methodology: This is a secondary review literature study where an electronic database search was conducted from 11th March, 2024 to 22nd April, 2024 searching for RCTs on treatment of LTBI in adolescents and adults PLHIV using 3HP conducted from 2010 to 2024 from Embase, Medline, PubMed, EBSCO, Cochrane database and ClinicalTrial.gov, Google Scholar, clinicalTrials.gov, International Clinical Trials Registry, Network Digital Library of Theses and Dissertations and the University of South Wales Library. The primary outcomes were the free survival Tuberculosis and treatment completion rates. Results. A total of 4 studies were identified that was included in data analysis where three studies compared 3HP with 6/9H in their studies and one study only used 3HP in the analysis of the primary outcome. Three studies were conducted in Africa and one in different continents. The studies showed 3HP to be effective in treatment of LTBI by preventing the development of active tuberculosis with reduction in mortalities. 3HP was associated with higher completion rates with higher adherence rates compared to longer duration treatments. Conclusion: 3HP proved to effective in treating LTBI in PLHIV by preventing development of active TB disease and reducing the all cause mortalities with demonstration of high compliance and completion rates, the gap remains as to what duration do 3HP provide the protective effect.
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How To Cite (APA)
Rushimabahizi, Kigumi Hamimu Omary, Kinonga Edward, & Mkombachepa Charles Rshidi (August-2024). THE EFFECTIVENESS OF 3HP ON TREATMENT OF LATENT TB INFECTION IN ADOLESCENT AND ADULT PLHIV IN TANZANIA:. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(8), a85-a91. https://ijnrd.org/papers/IJNRD2408009.pdf
Issue
Volume 9 Issue 8, August-2024
Pages : a85-a91
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Paper Reg. ID: IJNRD_226175
Published Paper Id: IJNRD2408009
Research Area: Medical Science
Author Type: Foreign Author
Country: Morogoro, Morogoro, Tanzania, United Republic of
Published Paper PDF: https://ijnrd.org/papers/IJNRD2408009.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2408009
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