Paper Title
Synthesis and biological evaluation of (N-(2-(4-methylpiperazine-1-carbonyl) thiophen-3-yl)-2-(piperazin-1-yl) acetamide hydrochloride and their sulfonamide derivatives
Article Identifiers
Authors
BHARTI DESHMUKH , Dr. Rakesh Srivastav , Dr. Srikanth Gawande
Keywords
Thiophene, Piperazine; Antioxidant; Antimicrobial.
Abstract
In our present study we have designed (N-(2-(4-methylpiperazine-1-carbonyl) thiophen-3-yl)-2-(piperazin-1-yl) acetamide hydrochloride (5a-j) and synthesized their sulphonamides derivatives (7a-j) by using heterocyclic scaffolds such as Thiophene and Piperazine by the application of molecular combination by simple covalent bond linkage such as carboxamide, sulphonamide, acetamide etc. Both the heterocyclic scaffolds have displayed their significance in the multiple pharmacological activities. Synthesized derivatives have been characterized by the application of spectroscopic techniques such as 1H/13C NMR, IR, Mass etc. and evaluated for their biological activities such as anti-microbial (antibacterial, anti-fungal) and antioxidant activities with assistance of Micro broth dilution method and DPPH assay respectively and compared with the reference standards such as Ampicillin, Nystatin and ascorbic acid. Most of the compounds have displayed antimicrobial activity against bacterial microorganisms such as Bacillus subtilis NCIM 2063, Bacillus subtilis NCIM 2063, Escherichia coli NCIM 2065, Proteus vulgaris NCIM 2813 and fungal microorganisms such as Aspergillus Niger NCIM 50, Candida albicans NCIM 3471 etc. studied in this research. Moreover, compound 7f have displayed prominent antibacterial activity against Proteus vulgaris NCIM 2813 (MIC 93.7 µg/ml) than reference standard ampicillin (MIC 125 µg/ml) and compound 7g, 7i (MIC 93.7 µg/ml) have displayed superior anti-fungal activity against Aspergillus Niger NCIM 50 than Nystatin (MIC 125 µg/ml). Antioxidant activities of the derivatives (7a-j) have shown more than 90% scavenging activity of the free radical and are almost similar to ascorbic acid (97.5 %) at 400µg/ml concentration.
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How To Cite (APA)
BHARTI DESHMUKH, Dr. Rakesh Srivastav, & Dr. Srikanth Gawande (July-2024). Synthesis and biological evaluation of (N-(2-(4-methylpiperazine-1-carbonyl) thiophen-3-yl)-2-(piperazin-1-yl) acetamide hydrochloride and their sulfonamide derivatives. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(7), g342-g351. https://ijnrd.org/papers/IJNRD2407539.pdf
Issue
Volume 9 Issue 7, July-2024
Pages : g342-g351
Other Publication Details
Paper Reg. ID: IJNRD_226122
Published Paper Id: IJNRD2407539
Downloads: 000121986
Research Area: Chemistry
Country: RAICHUR, KARNATAKA, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2407539.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2407539
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Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)
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