Synthesis and biological evaluation of (N-(2-(4-methylpiperazine-1-carbonyl) thiophen-3-yl)-2-(piperazin-1-yl) acetamide hydrochloride and their sulfonamide derivatives

Synthesis and biological evaluation of (N-(2-(4-methylpiperazine-1-carbonyl) thiophen-3-yl)-2-(piperazin-1-yl) acetamide hydrochloride and their sulfonamide derivatives

Registration ID: IJNRD_226122

Published ID: IJNRD2407539

DOI: Click Here to Get

BHARTI DESHMUKH , Dr. Rakesh Srivastav , Dr. Srikanth Gawande

Thiophene, Piperazine; Antioxidant; Antimicrobial.

In our present study we have designed (N-(2-(4-methylpiperazine-1-carbonyl) thiophen-3-yl)-2-(piperazin-1-yl) acetamide hydrochloride (5a-j) and synthesized their sulphonamides derivatives (7a-j) by using heterocyclic scaffolds such as Thiophene and Piperazine by the application of molecular combination by simple covalent bond linkage such as carboxamide, sulphonamide, acetamide etc. Both the heterocyclic scaffolds have displayed their significance in the multiple pharmacological activities. Synthesized derivatives have been characterized by the application of spectroscopic techniques such as 1H/13C NMR, IR, Mass etc. and evaluated for their biological activities such as anti-microbial (antibacterial, anti-fungal) and antioxidant activities with assistance of Micro broth dilution method and DPPH assay respectively and compared with the reference standards such as Ampicillin, Nystatin and ascorbic acid. Most of the compounds have displayed antimicrobial activity against bacterial microorganisms such as Bacillus subtilis NCIM 2063, Bacillus subtilis NCIM 2063, Escherichia coli NCIM 2065, Proteus vulgaris NCIM 2813 and fungal microorganisms such as Aspergillus Niger NCIM 50, Candida albicans NCIM 3471 etc. studied in this research. Moreover, compound 7f have displayed prominent antibacterial activity against Proteus vulgaris NCIM 2813 (MIC 93.7 µg/ml) than reference standard ampicillin (MIC 125 µg/ml) and compound 7g, 7i (MIC 93.7 µg/ml) have displayed superior anti-fungal activity against Aspergillus Niger NCIM 50 than Nystatin (MIC 125 µg/ml). Antioxidant activities of the derivatives (7a-j) have shown more than 90% scavenging activity of the free radical and are almost similar to ascorbic acid (97.5 %) at 400µg/ml concentration.

Published Paper   E-Certificate

"Synthesis and biological evaluation of (N-(2-(4-methylpiperazine-1-carbonyl) thiophen-3-yl)-2-(piperazin-1-yl) acetamide hydrochloride and their sulfonamide derivatives", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.9, Issue 7, page no.g342-g351, July-2024, Available :https://ijnrd.org/papers/IJNRD2407539.pdf

Volume 9 Issue 7, July-2024

Pages : g342-g351

Paper Reg. ID: IJNRD_226122

Published Paper Id: IJNRD2407539

Downloads: 000121189

Research Area: Chemistry

Country: RAICHUR, KARNATAKA, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2407539.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2407539

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJNRD (IJ Publication) Janvi Wave

This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition

Call For Paper - Volume 10 | Issue 8 | August 2025

IJNRD is Scholarly open access journals, Peer-reviewed, and Refereed Journals, High Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool), Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) with Open-Access Publications.

INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (IJNRD) aims to explore advances in research pertaining to applied, theoretical and experimental Technological studies. The goal is to promote scientific information interchange between researchers, developers, engineers, students, and practitioners working in and around the world. IJNRD will provide an opportunity for practitioners and educators of engineering field to exchange research evidence, models of best practice and innovative ideas.

Indexing In Google Scholar, SSRN, ResearcherID-Publons, Semantic Scholar | AI-Powered Research Tool, Microsoft Academic, Academia.edu, arXiv.org, Research Gate, CiteSeerX, ResearcherID Thomson Reuters, Mendeley : reference manager, DocStoc, ISSUU, Scribd, and many more

How to submit the paper?

Important Dates for Current issue

Paper Submission Open For: August 2025

Current Issue: Volume 10 | Issue 8

Last Date for Paper Submission: Till 31-Aug-2025

Notification of Review Result: Within 1-2 Days after Submitting paper.

Publication of Paper: Within 01-02 Days after Submititng documents.

Frequency: Monthly (12 issue Annually).

Journal Type: International Peer-reviewed, Refereed, and Open Access Journal.

Subject Category: Research Area